And when we experience that silence – we remember who we are.” ~ Gunilla Norris
In a time of universal deceit – telling the truth is a revolutionary act ~ George Orwell
Potential treatment for Lyme disease kills bacteria that may cause lingering symptoms, study finds Screening thousands of drugs, Stanford scientists determined that in mice, Azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease.
Deer ticks are vectors of Borrelia burgdorferi,
the bacteria that causes Lyme disease.
Scott Bauer/USDA Agricultural Research Service
May is National Lyme Disease Awareness Month, a chance for Lyme patients, activists and educators to spread information on how to prevent Lyme and tick-borne diseases. We’ve created a list of several things that you, your family, and friends, can do to help spread awareness. Lyme month – Bing images
For decades, the routine treatment for Lyme disease has been standard antibiotics, which usually kill off the infection. But for up to 20% of people with the tick-borne illness, the antibiotics don’t work, and lingering symptoms of muscle pain, fatigue and cognitive impairment can continue for years — sometimes indefinitely.
A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. The study suggests it could also be effective for treating patients infected with drug-tolerant bacteria that may cause lingering symptoms.
“This compound is just amazing,” said Jayakumar Rajadas, PhD, assistant professor of medicine and director of the Biomaterials and Advanced Drug Delivery Laboratory at the Stanford School of Medicine. “It clears the infection without a lot of side effects. We are hoping to repurpose it as an oral treatment for Lyme disease.” Rajadas is the senior author of the study, which was published online March 2 in Scientific Reports. The lead author is research associate Venkata Raveendra Pothineni, PhD.
“We have been screening potential drugs for six years,” Pothineni said. “We’ve screened almost 8,000 chemical compounds. We have tested 50 molecules in the dish. The most effective and safest molecules were tested in animal models. Along the way, I’ve met many people suffering with this horrible, lingering disease. Our main goal is to find the best compound for treating patients and stop this disease.”
Hunting for alternative drug
Frustrated by the lack of treatment options for Lyme disease patients with lingering symptoms, Rajadas and his team began hunting for a better alternative in 2011. In 2016, they published a study in Drug Design, Development and Therapy that listed 20 chemical compounds, from about 4,000, that were most effective at killing the infection in mice.
All 20 had been approved by the Food and Drug Administration for various uses. One, for instance, is used to treat alcohol abuse disorder.
Jayakumar Rajadas
In this most recent study, Azlocillin, one of the top-20 contenders,
was shown to eclipse a total of 7,450 compounds because it is more effective in killing B. burgdorferi and causes fewer side effects. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease Control and Prevention. It can affect various organs, including the brain, skin, heart, joints and nervous system, and cause heart problems and arthritis if untreated. Symptoms include fever, headaches, chills, and muscle and joint pain.
Traditional antibiotics, such as doxycycline, are effective as an early course of treatment for the infection in the majority of patients, but it remains unclear why these drugs fail to treat 10% to 20% of patients, Rajadas said. What are the Pros and Cons of Taking Doxycycline for Lyme Disease? (infobloom.com)
“Some researchers think this may be due to drug-tolerant bacteria living in the body and continuing to cause disease,” said Rajadas, who is also a member of the Lyme Disease Working Group at Stanford. “Others believe it’s an immune disorder caused by bacteria during the first exposure, which causes a perpetual inflammation condition. Whatever the cause, the pain for patients is still very real.” Azlocillin comes out on top.
The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillinwas also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.
Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.
Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.
Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist; postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD; senior research scientist Mohammed Inayathullah, PhD; and intern Mohammed Sohail Ahmed.
A researcher at Loyola College in India also contributed to the work.
The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.
Princeton University Prof Discovers New Breakthrough (healthfindings.website)
TIPS FROM THOSE THAT HAVE EXPERIENCE LYME DISEASE!!!
Realize I am not a DOCTOR, I truly feel you will get flare ups more often with lack of sleep and some type of food you are eating.. Your stomach will trigger most issues in your body.. Might even be a mineral or vitamin. Lack of sleep magnifies. It’s more than likely something you are eating that is healthy for most, but with your situation it reacts almost like poison to you.. I pay attention to dairy and whole grains to start.. They seem to cause many issues..
I hope you feel better soon.
Look into dnrs therapy. People recover from Lyme and many other things. Trust me.
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Sarah Jackson Panther – YouTube
I have Lyme too. I find if I eat too many carbs my joints get really stiff and sore.
Although they are complex carbs, veggies are still carbs.
Do you have any remedies that work for you?
Bartonella and Cancer | NB protocol (proboards.com)
Try sea moss gel, drink it in a smoothie – Bing video
I’ve had Lyme twice. Eat Meat. Drink Water. | Zen, and the Art of Zero-Carb Living (zerocarbzen.com)
Check out Medical Medium celery juice and Lyme Disease if you haven’t yet.
Anthony gives deep dives on the subject and how to heal.
Healing Lyme Disease and Hashimotos with Medical Medium
MMS Guide for Lymies – Lyme Recovery Clinic
My MMS Protocol for Curing Lyme Disease – Reclaiming Wisdom
DOXYCYCLINE. No more Lyme. That’s simple.
What are the Pros and Cons of Taking Doxycycline for Lyme Disease?
Eat meat. Don’t eat plants. Stop with Lyme disease.
The Carnivore Diet For Lyme: Could Less Really Be More? – Tired of Lyme
N-Acetylcysteine … Check it out, if you haven’t already..
Neuroinflammation & Lyme Disease – Naturopathic Doctor News and Review (ndnr.com)
What Is N-Acetyl Cysteine (NAC) And How Can It Help Fight Chronic Illness? | Make Well Nutritionals GmbHights-chronic-illness/?lang=en
Try http://criticalhealthnews.com I think Dr Wallach may have cured lyme I know he’s talked about dealing with it. I’m not sure though. In any case, I wish you the best. Stay strong!!! I doubt the sincerity of this Dr. Seems as if he is much more interested in selling a line of supplements than actually addressing the REAL issues that revolve around Lyme.
DETOX!!! Sweat as much and as often as you can. Be regimented with it. Yes, clearly stay away from bad foods and sugar, but there is no need for excessive supplementation, just eat a whole foods, limited carbs diet. No packaged stuff. I am about to try Essential Oil of Cinnamon to help eradicate my Lyme. Time will tell.
Lyme protocol according to Dr. Joel Wallach – YouTube
Search Results for Lyme Disease | Cancer Quick Facts (solitarius.org)