Angie Federico

J͏u͏l͏y͏ ͏3͏0͏ ͏a͏t͏ ͏5͏:͏3͏5͏ ͏P͏M͏ ·

When I say I have a deep, personal fucking beef with Anthony Fauci and the people who controlled the pandemic response, I need you to understand that I am talking about far more than politics, television interviews, congressional hearings, or whichever political team you think I am supposed to be defending.

I am talking about my sister-in-law, who was also one of my very best friends, dying after she repeatedly told a hospital that something was seriously wrong and they repeatedly sent her home anyway.

My sister-in-law was 31 years old when she was suddenly diagnosed with epilepsy after living her entire life without it, and the hospital prescribed her Tegretol to control the seizures. Within days of beginning that medication, she developed a rash that concerned her enough for my brother to take her back to the same hospital that had diagnosed her and prescribed the drug.

She showed them the rash, explained that she had just started taking Tegretol, and told them that she believed she was having an allergic reaction. The hospital sent her home with instructions to take Benadryl and continue taking the medication exactly as prescribed, so she trusted the medical professionals who told her she was safe and followed their instructions.

Within a few more days, the rash became hives that continued spreading across her body, and my brother rushed her back to the emergency room because the reaction was clearly getting worse. She once again showed them what was happening to her skin, reminded them about the new medication, and told them that she believed she was having an allergic reaction.

They sent her home again with the same instructions to take Benadryl and continue taking the Tegretol.

And this is where the COVID restrictions became a devastating part of the story, because my brother was prohibited from entering the emergency room with his wife and advocating for her in the way he normally would have.

My sister-in-law was an immigrant from Burma, and while she spoke fluent English, English was not her first language. So my brother was the person who usually stood beside her during medical appointments, helped her explain exactly what she was experiencing, asked the questions she may not have known to ask, and pushed harder when he felt that something important was being dismissed.

He explained all of that to the hospital, pleaded with them to let him accompany his wife, and made it clear that his presence mattered because he knew her medical history and could help her communicate. But they refused to let him through the doors and assured him that they would take care of her…

And once again, they sent her home with the same instructions (take Benadryl, keep taking the seizure meds).

Within another day, the hives began turning into painful blisters and open wounds, her eyes were burning, she felt feverish, and my brother rushed her back to the hospital for the third time because her body was now showing every possible sign that this had become a medical catastrophe.

This time, they finally admitted her.

The doctors eventually diagnosed her with Stevens-Johnson syndrome, a rare and devastating reaction to medication that was destroying her skin and ravaging her entire body from the inside out. Then the hospital kept her for several more days before calling my brother and admitting that they were not properly equipped to treat her condition, so they transferred her to another hospital with a specialized burn ICU.

By the time my brother was finally allowed to see his wife, she could no longer open her eyes, and more than 95% of her body had been affected by third degree burns and wounds (yes, 3rd degree burns).

She was still conscious at this point, she was still speaking, and she was still the woman my brother loved trapped inside a body that was being destroyed by the same medication she had repeatedly told the first hospital was hurting her.

About 72 hours later, the hospital called my brother and told him to come immediately because the doctors needed to speak with him… and I was the one that drove him there because there are certain phone calls that tell you everything before anybody has said the actual words.

A nurse met us at the entrance because she was supposed to escort my brother upstairs alone, and security initially planned to stop me from going with him because the COVID restrictions still limited who could enter the hospital. That nurse knew the news my brother was about to receive, understood how incredibly cruel it would have been to force him to hear it by himself, and she fought for me to accompany him.

(I never learned her name, but I will thank God for that woman for the rest of my life because she gave my brother the dignity of having somebody beside him when his entire world collapsed.)

She led us into a conference room inside the burn ICU, and a doctor came in to explain that my sister-in-law had become septic, her organs were failing, and the damage had progressed beyond anything they could treat.

I will never forget my brother looking directly at that doctor and saying, “Look me in the eye, doc, man to man, and tell me. Is my wife coming home?”

The doctor looked completely defeated, let out an empathetic sigh, and shook his head and told him, “no.”

I remember letting out the words, “Oh my God,” while my brother froze so completely that it looked like his body had forgotten how to breathe.

My brother stepped out of the room to process what he had just heard, and the doctor sat next to me and asked me what had happened before my sister-in-law arrived at their facility because he was so confused and sad for us and had been under the impression that his hospital was the first place to treat her.

Then I explained the epilepsy diagnosis, the Tegretol, the first rash, the spreading hives, the repeated emergency room visits, the instructions to continue taking the medication, and the fact that my brother had been forced to remain outside while his wife tried to advocate for herself alone…

I will never forget the disbelief and concern that came over that doctor’s face as he listened, because he understood how many times she had asked for help before she reached him.

He became extremely careful with his words, and I understood why, because multiple hospitals had been involved and there were serious questions surrounding how her case had been handled. All he could finally say was “I am so sorry…” before he walked us into her room where my brother could say goodbye to his wife.

To say my sister-in-law was completely unrecognizable is an understatement.

I watched my brother stand beside the woman he loved for over 10 years while she lay covered in burns and wounds, her organs failing, and her body unable to survive what had happened to her…

My brother gently stroked her head and sob as he said, “Goodbye, my love.”

I watched the numbers on the monitor begin to fall after they removed her from life support, and when her heart reached its final beats, my brother looked at the screen, looked back at his wife, and sobbed again in agony and softly said, “Oh… I know what that means.”

Then the monitor went flat.

It was around 1:30 in the afternoon.

I walked beside my brother through what felt like the longest hallway on the face of the Earth back to my car, carrying his wife’s belongings while he whimpered, “Oh man… oh man…” over and over because those were the only words he could manage to say.

When we reached my car, his crying suddenly stopped, and at the first traffic light outside the hospital, he asked me to do him a solid and stop at a gas station so he could buy cigarettes. He had quit smoking a years before then, but after watching him have to take the love of his life off of life support, I sure as hell was not going to deny him that one small request.

When he got out of my car, I watched him walk into that gas station store with a dazed look all over his face, and I just knew that nothing would ever be the same after that day.

Because I knew that a massive part of my brother had died inside that hospital room with his wife that day.

Over the following years, he turned to alcohol because he did not know how to make that level of grief stop hurting… and last August, alcoholic liver failure took him too.

I received another hospital phone call, sat inside another conference room, listened to another doctor explain that someone I loved would never come home, and watched another heart slow down on another monitor until it stopped.

Now my niece and my youngest nephew have lost both their mommy and daddy, which means the damage did not end when my sister-in-law’s heart stopped beating… because it created a dark ripple effect that continued tearing through our family for years.

So when I say that I have a personal fucking beef with Anthony Fauci and every official who created, enforced, defended, and celebrated pandemic policies that separated vulnerable patients from the people who knew them best, this is the grief I am talking about.

My anger comes from knowing that my sister-in-law repeatedly asked for help and was treated like her concerns were insignificant.

It comes from knowing that she was instructed to continue taking the medication she believed was hurting her.

It comes from knowing that my brother fought to stand beside his wife and was kept outside while the hospital assured him that she would be taken care of.

It comes from knowing that an immigrant woman who spoke English as her second language was forced to advocate for herself alone during one of the most terrifying medical emergencies of her life.

It comes from knowing that had she been treated with urgency the first time she walked through those doors, or had my brother been allowed to fight for her from inside the room, the outcome could have been different.

And my family’s experience with those restrictions did not end there, because my grandmother also died alone inside her assisted-living facility while visitors were prohibited during COVID.

She had advanced dementia, and the people she recognized, trusted, and loved were kept away from her during the final season of her life. My last living grandparent left this world without her family beside her to hold her hand or say goodbye, and that is a grief I will carry for the rest of my life too.

Yes, COVID was real, and yes, COVID killed an unimaginable number of people, but acknowledging the reality of the virus does not require me to pretend that every policy created in response to it was compassionate, justified, effective, or harmless.

People in positions of power used an emergency to make sweeping decisions that stripped patients and families of their voices, removed advocates from hospital rooms, isolated vulnerable people from the humans who loved them, and created consequences that will never be captured by a case count or government report.

My family became part of those consequences.

So yes, I struggle with anger, and there are days when forgiveness feels almost impossible because the grief has names, faces, hospital rooms, conference tables, flatlining monitors, and children who will spend the rest of their lives missing their parents. Biden admin restarts bat virus research grant that funded Wuhan lab, coronavirus testing | Fox News

Live: Anthony Fauci pleads Fifth at Senate hearing, lawyer removed from room

Anthony Fauci is a NAZI – Search

And yet, I still pray for Anthony Fauci.

I pray for the hospital workers who dismissed my sister-in-law.

I pray for the officials who created policies that separated sick people from their advocates and dying people from their families.

I pray because every one of them is human, every one of them is a sinner, and every one of them needs the mercy of God exactly as desperately as I do.

But prayer does not require amnesia, forgiveness does not remove accountability, and mercy does not require me to sanitize the truth so that the people involved can feel more comfortable with the consequences of what happened.

My sister-in-law deserved to be believed the first time she asked for help, my brother deserved to stand beside his wife and advocate for her, my niece and nephews deserved to grow up with their parents, and my grandmother deserved to leave this world surrounded by the family who loved her.

So I will continue praying for everyone involved, and I will continue telling the truth about what their decisions cost my family, because both realities exist inside me at the same time.

I am a Christian woman trying to forgive, and I am also a grieving sister, aunt, granddaughter, and friend carrying a very personal, very painful, and very fucking justified anger over lives that deserved better.

God help me, some days carrying both feels heavier than I know how to explain.

Carlos Charlie M. Gonzalez

1͏9͏m͏ ·

I am so sorry for everything you all went through.

This happens to thousands of families because this is our medical system and people do not know to question everything and to get second and third opinions. They do not know because no one gave them options, natural health practitioners etc.

I was going to study to become a surgeon while being stationed in the Air Force and learned of how the medical system works while working at this Air Force training hospital and decided I did not want to be a part of that. I instead had an incident of severe back pain that led me to discover Chiropractic.

36 years later I still try to educate my patients and followers on social media of the dangers of so called “medicine” which are synthetic toxic petroleum based drugs with MANY SIDE EFFECTS and those include all vaccines, flu shots etc. At nearly 70 I take no prescription drugs, I do not go to medical doctors.

But if there is a life threatening situation like a gunshot wound, stab wound, broken bone, heart attack, severe burn then Emergency Rooms are you best choice. Other than those situations there are SO MANY NATURAL SAFE WAYS TO HEAL THE BODY. Please find a positive way to channel that anger to help others awaken from the dangers of the medical system

‘The Girl That Does Those Crazy Swims’: Maya Merhige… | SwimTrek

Teen swimmer Maya Merhige’s Oceans Seven goal turns spotlight on fight against cancer

Ansley Gavlak

USA TODAY

July 25, 2026 Updated July 27, 2026, 11:03 a.m. ET – Search

What is Maya Merhige’s next Oceans Seven challenge swim?

How much has Maya Merhige raised for cancer research?

Teen ultra‑marathon swimmer Maya Merhige is pursuing the Oceans Seven challenge to raise funds for cancer research, aiming to become the youngest ever to complete the seven toughest open‑water swims before turning 20.

One of ultra-marathon swimmer Maya Merhige’s biggest fears is jellyfish. Yet she willingly spends hours swimming through some of the world’s largest and most dangerous bodies of water.

Why?

Because she swims for those who can’t.

Every time Merhige jumps into freezing water surrounded by sharks and jellyfish, she is raising money for cancer research and patient programs through the nonprofit Swim Across America.

“If those patients can do cancer treatment – if those 7-year-olds and 4-year-olds can go through a day of cancer treatment – then I can most definitely swim another 20 strokes,” Merhige says.

High School Sports: The best preps coverage in the country, from rankings, scores and stats to local and national news—every team matters.

So far, Merhige, 18, has raised more than $172,000 for cancer research.

Teen Girl Battles Jellyfish to Complete 27-mile Swim–May Soon Be Youngest to Finish the Top 7 Ocean Challenges
She aims to become the youngest person to complete the Oceans Seven challenge, a series of the world’s seven most difficult open-water swims. The record belongs to Caitlin O’Reilly, who completed the challenge at 20 years, 227 days old.

On July 8, Merhige completed the fifth swim of the challenge, a 21.4-mile crossing of the North Channel from Ireland to Scotland. Battling 50-degree water, powerful tides and jellyfish stings, she finished in 12 hours, 19 minutes and 37 seconds.

Maya Merhige prepares to swim across the North Channel on July 8, 2026 as a part of the Oceans Seven challenge.
This swim held special significance for Merhige: It took place exactly a year after she had major surgery. After she had a ski accident in 2023, doctors discovered a benign tumor on her pancreas that led to several years of hospital visits and surgeries.

“I think it completely changed my perspective and my understanding of what the cancer experience is like,” she says. “The fact that I can do this and I’m healthy enough to do this – I shouldn’t take advantage of that.”

Maya Merhige – Swim Across America

Before Merhige began the Ocean Seven challenge, she became the youngest woman to swim the width of Lake Tahoe at just 13 years old. She then began the challenge with the Catalina Channel as a freshman in high school, becoming the youngest woman to complete the 20-mile swim at age 14.

One year later, she became the youngest person to complete the Molokai Channel swim in Hawaii at age 15. She followed that by crossing the Cook Strait in New Zealand, the English Channel and the Molokai Channel. But those feats didn’t come easily, she says.

“It took me a long time until maybe a year ago to really be OK with not having a lot of control and not having complete awareness all the time. That really scared me at the beginning – the feeling of being so small in such a big body of water.”

Each swim must be completed solo and unassisted. Swimmers cannot touch a buoy, the boat or any passengers. Every 30 minutes, Merhige is handed a water bottle on a rope filled with carbohydrates to stay fueled, though even that can be difficult when she begins to feel sick.

Despite the physical challenges, Merhige says, the mental challenge is even greater.  Instagram

“I have swum for a long time, so I know that physically I can. It’s much more a mental thing to be like, ‘How can I continue doing this and not stress myself out?’”

The Molokai Channel swim was the toughest of the five swims, she says – physically and mentally. She was in the water for 28 hours, nearly twice as long as she and her crew had expected.

“I had such a challenging time,” Merhige says. “That was the only time I’ve ever been in the water and been like, ‘Why do I do this?’”

But whenever she questions her decision to continue, she reminds herself for whom she is swimming. Before every open-water swim,  Maya Merhige writes the names of those who have been affected by cancer on her cap before every swim. From family members to friends and even cancer patients she doesn’t know, each name serves as a reminder of why she keeps going.

Merhige has raised more than $172,000 for cancer research.
Merhige has two swims remaining to complete the Oceans Seven challenge. She is scheduled to swim the Strait of Gibraltar in August and complete the Tsugaru Strait in Japan next year – both before her 20th birthday.

Before each swim, she’ll write the names of cancer patients and survivors across her cap, just as she always does.

“I like to say that I borrow their bravery.”

References

1.  Choi, Kenny (2023-10-13). “East Bay teen raises funds to fight cancer with open-water swimming – CBS San Francisco”. www.cbsnews.com. Retrieved 2024-08-03.
2.  Onque, Renée (2023-07-20). “This 15-year-old swam 28.5 miles around the island of Manhattan: ‘I didn’t know that I was breaking records'”. CNBC. Retrieved 2024-08-03.
3.  Moses, Claire (2024-07-30). “At 17, She’s Already Conquered Some of the World’s Big Swims”. The New York Times. ISSN 0362-4331. Retrieved 2024-08-03.
4.  “14 year old breaks swimming record in Lake Tahoe”. KTVU FOX 2. 2022-07-23. Retrieved 2024-08-03.
5.  “14-year-old Berkeley native becomes youngest to swim Lake Tahoe”. KRON4. 2022-07-28. Retrieved 2024-08-03.

Teen Girl Battles Jellyfish to Complete 27-mile Swim–May Soon Be Youngest to Finish the Top 7 Ocean Challenges

Berkeley teen raises funds to fight cancer with daring open water swims – KVIA

Berkeley teen raises funds to fight cancer with daring open water swims – CBS San Francisco

18-Year-Old Marathon Swimmer Maya Merhige Attempts North Channel Swim with the Goal To Become The Youngest to Complete the Oceans Seven – Swim Across America

Berkeley teen swims from Ireland to Scotland

He Survived 438 Days Alone in the Ocean! #shorts #history #SurvivalStory

41 Days Alone in the Ocean | A True Survival Story That Shocked the World

Francisco Lopera. [ Courtesy of the Consorcio de América Latina y el Caribe sobre la Demencia (LAC-CD).]

Dr. Francisco Javier Lopera Restrepo (1951-2024) As a young country doctor in the early 1980s, Lopera realized that the villages in the mountainous Paisa region around Medellin where he had grown up were home to families beset with a heritable form of early onset dementia. Since then, Lopera focused his clinical work and his research on these families and their disease. The result?

In large part, the Alzheimer’s Prevention Initiative. The API, together with its cousin, the Dominantly Inherited Alzheimer’s Network (DIAN), has pioneered therapeutic intervention trials founded on large-scale human data gleaned from decades-long clinical and biomarker studies of deeply phenotyped cohorts.

This description hardly reflects the effort involved. Early on, Lopera and colleagues traced afflicted families and their genealogies, building pedigrees that pointed to a founder mutation in the 18th century. Lopera forged international collaborations with Ken Kosik, Alison Goate, and Cindy Lemere, and, in the 1990s, co-authored seminal papers on the presenilin 1 gene and the E280A mutation that caused autosomal-dominant Alzheimer’s disease, named Paisa after its origin region (Alzheimer’s Disease Collaborative Group et al., 1995; Lemere et al., 1996; Lendon et al., 1997; Lopera et al., 1997).

By and by, Lopera built the interdisciplinary Grupo Neurociencias de Antioquia at the University of Antioquia in Medellin. By the late 2000s, Lopera, with many colleagues, students and mentees, had collected information on, and built clinical care for and research relationships with, a thousand members of this kindred.

This was the largest Alzheimer’s kindred known at the time, but it was only a start. When in 2008 Lopera met Eric Reiman, Banner Alzheimer’s Institute in Phoenix, the two joined forces with Banner’s Pierre Tariot and Jessica Langbaum to make prevention trials a reality. For that, the Colombian API registry needed to grow, and now, in 2024, it contains 6,000 kindred members from age 7 to the late 70s, of whom 1,200 carry the mutation that leads to MCI at around age 44, and dementia by 49.

Lopera embraced Reiman’s idea of working to help his families in a way that would help AD patients across the world. When Reiman and U.S. colleagues visited Colombia in 2008, Lopera introduced them to a gathering of 700 family members and took them to visit affected families in their homes. “It was a life-changing experience,” Reiman recalled.

In 2009 and in 2010, the API scientists convened leading AD researchers, funders, FDA regulators, drug developers, and others to persuade them that the time had come, and the tools were in place, to start FDA license-enabling trials of the most promising investigational drugs in cognitively normal people whose genetics and biomarker profiles put them within five years or so of developing Alzheimer’s symptoms (Feb 2010 news series).

Until then, leaders in the field had been paying lip service to this idea, calling it premature. At these gatherings, the pendulum swung toward action. “At the end, we went around the table, asking each participant for their concluding thoughts. Francisco was the last person to speak. When it was his turn, he simply said ‘My families are waiting,’ and everyone understood,” Reiman wrote in a 2023 letter recommending Lopera for the Potamkin Prize, which he won in 2024 (Mar 2010 conference news).

Francisco Lopera ringed by microphones and cameras at a GNA media event. Yakeel Quiroz, MGH, in red jacket on right. [Courtesy of Pierre Tariot.]

By 2011, API was in full gear, planning in detail for trials, bringing in more expertise. Media companies had caught on and were flocking to Medellin. In 2012, then-NIH director Francis Collins announced federal funding for API’s Colombia trial as part of the U.S. National Plan to Address Alzheimer’s (March 2011 news series; May 2012 news).    READ MORE  A Country Doctor, But Oh So Much More: Francisco Lopera, 73 | ALZFORUM

  Remembering Francisco Lopera: A pioneer in the study of familial Alzheimer… | MedLink Neurology

On Tuesday September 10, 2024. Francisco Lopera died of cancer at his home in Medellin, Colombia. He was 73, and only just beginning to see his life’s work come to fruition. 

Francisco Lopera (June 10, 1951 – September 10, 2024) was a Colombian neurologist who made major discoveries in the field of Alzheimer’s. He was a professor at the University of Antioquia in Medellín. He identified the world’s largest extended family with Alzheimer’s which he studied for decades and identified the genetic cause of their disease.^[1] 

• Kenneth Kosik
  University of California, Santa Barbara
• Posted: 16 Sep 2024

Francisco Lopera: A Memory and a Tribute

Autumn already!–But why regret an eternal sun if we are embarked on the discovery of divine light–far from all those who fret over seasons.—Arthur Rimbaud

.

Farewell, Pacho. How grateful I am to have had a moment of farewell, to say goodbye when still the sparkle in your eyes remained.

Dr. Francisco Javier Lopera Restrepo (1951-2024)

Three and half decades ago, in 1989, Francisco Lopera told me about a very large family who suffered from dementia with onset in their late 40s. That moment began a collaboration rare among scientists for its uninterrupted duration. He and Lucia Madrigal had pieced together on tattered scraps of paper a family tree that, when pasted together and unfurled across a table, revealed hundreds of individuals, a number that later grew to thousands.

Among the intertwining connections of marriages, of sons and daughters, of aunts and uncles, numerous cousins, and remote ancestors, what was apparent as Francisco listened to their stories was the fearsome presence of a disease that haunted them all. Thirty-five years ago, we did not know what that disease was until the first affected individual donated her brain and Juan Carlos Arrango flew with the brain to my house, in Boston at the time.

It was 11 p.m. when he knocked on my door with a bucket and a brain in formalin. The next morning, we cut and stained the brain and confirmed the clinical suspicion of Alzheimer’s disease with all the diagnostic hallmarks of plaques and tangles. Today, the brain bank in Colombia known as NeuroBanco contains about 500 brains and has been an invaluable source of tissue for research.

A few years after proving the Alzheimer diagnosis, in collaboration with Alison Goate, the responsible mutation was identified in presenilin 1 as a substitution of a glutamic acid for an alanine at position 280. Blood samples for this analysis had been collected over the previous years and stored in refrigerators that lost power numerous times during those tumultuous years, often leaving dried blood along the walls of the tube. Once found, the mutation became known as the paisa mutation in recognition of the people in Antioquia and a few surrounding states called paisas. One stereotype of the paisas is that they are a proud people. 

On one occasion when I gave a talk in Cali there was a chuckle in the audience when I mentioned the paisa mutation. I asked what was funny. After all, the mutation causes a devastating disease. They said yes, of course, but the paisa are so proud, they are even proud of their mutation. The meaning of pride has changed since it made the list as one of the seven deadly sins to become a virtue regarding a sense of belonging to a group, and so was it with Francisco, a man deeply attached to his identity as a paisa. Despite offers from institutions all over the world he remained in Colombia, dedicated and at home.

Over the following years we traveled to the pueblitos of Antioquia through mountainous passes along winding roads, often stuck behind an exhaust-spewing overloaded truck struggling up the steep grade. These five- or six-hour trips began early in the morning, and after about two hours we always stopped for fresh pan de yuca and café con leche. Francisco pointed out a bend in the road on the way to San Raphael that was famous for kidnappings.

 Along with us, sometimes in a van, sometimes in an SUV, were Lucia and members of the Grupo Neurociencias team from the university. Conversation was boisterous and animated on the way out and sleepy on the return. Francisco, who was rousing, even a bit verbose when he delivered remarks to the family, listened quietly to the running chatter of the team.

With some advance planning at our destinations, the extended family gathered to receive us with big welcoming greetings and hugs. We walked into a modest home with 20 or 30 people already there and more coming and going as the day wore on. We brought snacks and juice boxes and sometimes the family prepared dinner for us. Most were family, a few were onlookers, as very little is private in the small towns and neighborhoods. 

The team wasted no time, first explaining our mission, to describe the disease which they knew all too well, the flip-of-a-coin inheritance pattern of an autosomal-dominant disease, the data collection process, and the acquisition of blood samples after carefully explaining informed consent to each subject.

The most animated moments were drawing the family trees. Family members huddled around Francisco as he asked about the parents and grandparents, the siblings and children, those affected and those who were healthy. Sometimes a key informant was missing, but a call to a neighbor reached a cousin who might open another branch of the family. 

Glances and half smiles across the room suggested more than was being said about paternity. In every family, there was at least one young man whose death was called an accident, but usually meant a murder. In this painstaking way, the family tree grew to thousands and new founder mutations surfaced. This was medical practice in reverse—not, they come to us, but rather, we go to them.

Colombia is a country of many wonders. It is a place of dreams and nightmares, of outlandish notions and mystical beliefs. It is not surprising that such a country has produced such a remarkable person as Francisco, as it has others whose global impact extends far beyond the small size of the country. In 2018, I flew with Francisco, his wife, Claramonika, and his daughter Karina to Acandí and from there we took a speed boat called a chalupa to Sapzurro near the Panamanian border. 

Like everything in Colombia—food, accents, slang—boats, too, are highly regionalized. We took a planchon to travel down the Sinú River to an indigenous village outside Monteria, a Johnson river boat to cross the Magdalena in the town of Suán. Sapzurro is the tiny town where Francisco did his “rural,” Colombia’s obligatory year of service after medical school. His medical school colleague Rafa joined us and they devoured chicharrones. An older woman there remembered him as the doctor who delivered her baby. She was effusive to see him.   

For many years Francisco did this work in obscurity, with little money and zero recognition. I faced criticism from colleagues for what they saw as a human-interest story devoid of science. That began to change in 2004, when I brought Eric Reiman to Colombia and introduced him to Francisco.

At last, the dream of offering hope in the form of a clinical trial could be realized. This hope had been part of every family visit, and soon, with the extraordinary efforts of Carole Ho, a clinical trial was on the drawing board. From the barrios of Medellin to the remote countryside, where healing was often in the hands of the bruja, or witch doctor, people endorsed a scientific trial that could benefit Alzheimer patients worldwide.

I recall the first chapter of One Hundred Years of Solitude, in which the village people of Macondo lose their memories until one day a gypsy arrives and brings una sustancia de color apacible, a substance of a gentle color, and restores their memory. We sought the substance.

If we go looking for la sustancia de color apacible, we’re not just searching for an ingredient in a gypsy’s satchel—we’re tracing one of the deepest metaphors in Cien años de soledad: the possibility of recovering what a community has forgotten about itself.

Here’s where the search truly begins.

What restores memory in our own lives? What is our gentle-colored substance?

It might be:

• stories,
• rituals,
• objects,
• places,
• people who return unexpectedly,
• or the act of remembering itself.

Seeking the substance becomes a philosophical quest: How do we recover what we’ve forgotten about ourselves?

The gentle-colored substance restores not just memory but the ability to interpret reality.

It symbolizes the return of sense, context, and coherence.

This is why its color matters: it is apacible, calming, like the return of order after chaos.

The gentle-colored substance is the first symbolic gesture toward the idea that memory is salvation. It foreshadows the ending, where the final Buendía discovers the truth only by reading Melquíades’s manuscript—another “substance” that restores memory.

The substance symbolizes the act of reading as an act of remembering, and remembering as an act of healing.

Let’s take a stroll down memory lane Bing Videos

🧭 In one line

The gentle-colored substance is the quiet, luminous force that restores meaning, identity, and history—both to Macondo and to the reader.

The Memory-Reset Scene in One Hundred Years of Solitude

In the opening chapter of One Hundred Years of Solitude, the narrator — later revealed to be Colonel Aureliano Buendía — is facing a firing squad and recalls the founding of Macondo. At that time, the village was small, isolated, and still in a state of “recent” creation, with many things unnamed and only indicated by pointing Archive.

Every year, a caravan of gypsies visited Macondo, bringing “new inventions” that astonished the villagers. These included a powerful magnet, a telescope, and a magnifying glass. José Arcadio Buendía, the town’s founder, was fascinated by these objects and often imagined extraordinary uses for them LitCharts+1.

The memory-reset moment you recall is not literally described in the text as a gypsy bringing “una sustancia de color apacible” (a substance of a gentle color) to restore memories. Instead, the chapter’s opening is a flashback to a time when the people of Macondo had lost their memories — a state of collective amnesia that had been ongoing for some time. The gypsies’ arrival and their display of objects (especially the magnet) were part of the cycle of wonder and forgetting that defined Macondo’s early years LitCharts+1.

The “restoration” of memory is more symbolic: the gypsies’ gifts and José Arcadio Buendía’s experiments with them represent the introduction of external knowledge and technology into a society that had been cut off from the outside world. This act of introducing new things — the magnet, the telescope, the magnifying glass — is what triggers the memory of the past, even if the text does not name a specific “gentle-colored substance” as the memory-restorer.

In short, the memory-reset scene is a metaphor for the moment when Macondo is reintroduced to the world through the gypsies’ inventions, and through José Arcadio Buendía’s curiosity, the people begin to remember their history. The “gentle-colored substance” you recall is likely a poetic interpretation of the gypsies’ gifts, which serve as the catalyst for the memory’s return.

We now know the clinical trial did not show a therapeutic effect of treatment. But this trial was conducted like no other trial ever, thanks to the massive amount of groundwork laid down by Francisco as well as others including Lucia Madrigal, Silvia Rios, and David Aguillón, and most importantly, the trust the families placed in Francisco.

This was a trial on a single family who all shared the same point mutation and shared a mostly similar socio-economic status. That platform to which numerous subjects donated their time and their bodies remains, and the population continues to collaborate with new trials that will be one of the many legacies left by Francisco.

More science came in 2019 when the APOE3 Christchurch variant was suggested by Yakeel Quiroz and Joseph Arboleda as the basis for delaying the onset of familial Alzheimer’s disease caused by the presenilin mutation. The discovery of this variant has spurred international research efforts to understand the mechanism of this protective effect.

Family trees conceal untold stories of love and romance, of death and despair. We all experience tragedy and joy but in Colombia the mix differs. Somehow both happen simultaneously. Like when I saw Francisco in his last days—unable to talk or move—and showed him some slides of our memories. One of them was me falling off a hammock at the finca, and from some unsuspected reserve, he laughed.

Valley of Forgetting: Alzheimer’s Families and the Search for a Cure by Jennie Erin Smith

Francisco Lopera, the man who dreamed of curing his grandmother

Starting in the 1980s, neurologist Francisco Lopera began riding horseback through the mountains of his home country, Colombia, to explore a medical mystery that had been debilitating and killing people for centuries. In certain villages, residents routinely began suffering severe memory loss before middle age, then dying in their 50s. Lopera discovered that a rare genetic mutation was causing early onset Alzheimer’s disease. 

He set out to avert it. 

 Jennie Erin Smith — an award-winning American science journalist and author — chronicles that work, following the neurologist, the families, and the research carried out in labs and through clinical trials. With the storytelling skills of a novelist, Smith shows in flesh and blood what happens when communities serve as sites for scientific investigation. The experiences are both uplifting and uncomfortable, raising questions about vulnerability, consent, and hope. 

For example: How do scientists communicate reality to villagers who excitedly sign up for the trials believing they will be cured? This was named among the best books of 2025 by The New Yorker and The Wall Street Journal.

Cardiologists wish you would stop doing these things for high blood pressure

1. These are results for Uncontrolled Blood Pressure can cause vascular dementia.
2. LikeDislikeHow Uncontrolled Blood Pressure Can Cause Vascular DementiaUncontrolled high blood pressure (hypertension) is a major risk factor for vascular dementia, the second most common type of dementia after Alzheimer’s disease Blood Pressure UK+1. Over time, persistently elevated blood pressure can damage the brain’s blood vessels, reducing oxygen and nutrient supply to brain cells and leading to cognitive decline.How High Blood Pressure Damages Brain Vessels
   • Small vessel disease: Chronic high blood pressure causes small brain vessels to become narrow, stiff, and less elastic, impairing blood flow to brain regions responsible for thinking, memory, and judgment Blood Pressure UK+1.
3. • Stroke and TIA: High blood pressure increases the risk of stroke (permanent vessel blockage or rupture) and transient ischemic attacks (mini-strokes), which can cause post-stroke dementia or multi-infarct dementia Blood Pressure UK+1.
4. • Silent damage: Even without a single major stroke, years of micro-damage to small vessels can accumulate, leading to widespread brain hypoperfusion and neuronal injury helpdementia.com.
   Why This Matters
   • Vascular dementia results from reduced blood flow to the brain, starving brain cells of oxygen and nutrients Blood Pressure UK+1.The brain is highly sensitive to even brief reductions in blood flow; chronic underflow can cause permanent damage helpdementia.com.People with mid-life hypertension are more likely to develop dementia in later life, especially vascular dementia Alzheimer’s Society.
   Prevention and Management
   • Control blood pressure: Keeping it within target ranges (e.g., <150/90 mm Hg for most adults, with individualized goals) can significantly lower the risk of vascular dementia Johns Hopkins Medicine+1.
5. • Lifestyle changes: Healthy diet, regular exercise, weight management, limiting alcohol, and quitting smoking help protect blood vessels Alzheimer’s Society.
6. • Medication: Antihypertensive drugs can reduce dementia risk, and some studies show they may slow progression in those already diagnosed Johns Hopkins Medicine+1.
   Bottom line: Uncontrolled blood pressure can silently damage brain blood vessels over years, leading to vascular dementia. Managing blood pressure early and consistently is one of the most effective ways to prevent or slow this type of cognitive decline Blood Pressure UK+2.

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Francisco Lopera, the man who dreamed of curing his grandmother

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Kai Trump reveals diet and nutrition secrets that created six-pack abs post-surgery

Donald Trump’s granddaughter eats 150 grams of protein daily while following a gluten-free and dairy-free diet

By Angelica Stabile Fox News

Kai Trump reveals her eating plan, gym routine and wellness priorities

Kai Trump explains how her mother’s example influenced her food choices, while social media helped her develop routines she considers realistic, sustainable and easy to maintain.

Kai Trump is fueling her golf game with a protein-packed diet, clean meals and a disciplined fitness routine.

In an interview with Fox News Digital, President Donald Trump’s eldest grandchild, 19, discussed how she stays healthy and fit as an athlete, sharing that she eats “a lot of protein.”

“I weigh 120 pounds and I probably eat around 150 grams of protein,” she said. “[I] eat a lot of sustainable carbs and work out a lot.”

The competitive golfer, who is joining the University of Miami Women’s Golf team when she starts college this fall, said she also follows a gluten-free and dairy-free diet, and avoids eggs due to a slight allergy.

Despite her demanding schedule, she makes a point of fueling her body with protein-rich foods rather than skipping meals.

Kai Trump plays her tee shot on the 14th hole during The Annika driven by Gainbridge at Pelican Golf Club in Belleair, Florida, Nov. 14, 2025. (Brian Spurlock/Icon Sportswire via Getty Images)

“No matter what I’m doing, I always have like 40 grams of protein in the morning through a shake or something, just so I have it in my system,” she told Fox News Digital. 

“So, if I run or I’m doing something crazy, at least I have that. I got that protein in.”

The young influencer revealed that her favorite go-to dish is a ground beef bowl, which she prepares with rice, avocado and some seasonings.

“I eat very clean and simple,” she said. “I would be totally fine eating steak for the rest of my life, or just chicken and rice, which is weird to some people, but I like it.”

Kai Trump and Ivanka Trump are pictured paddleboarding together in the Bahamas. (Ivanka Trump/Instagram)

When she does decide to indulge in a “guilty pleasure” snack, Kai said she never reaches for sweets, but rather some prosciutto with pesto.

She said her mother, Vanessa Trump, who is in “great shape,” helped instill the healthy habits that Kai follows today.

“Seeing how she eats and what she prioritizes … I kind of grew into that,” she shared.

Don Trump Jr.’s oldest child said her healthy lifestyle paid off after wrist surgery  temporarily sidelined her from golf. Rather than viewing the recovery as downtime, she told friends that she planned to use the time to achieve “six-pack” abs.

Kai Trump visits “Fox & Friends” at Fox News Channel Studios on July 16, 2026, in New York City. (Dominik Bindl/Getty Images)

“I literally told them, ‘I have seven months before I return to golf, we’re getting a six-pack,’” she said. “And I got a six-pack literally just by prioritizing the right foods and working out.”

Kai credited that transformation to consistent workouts and a nutritious diet.

At the gym, she follows a well-rounded routine that includes core exercises, squats and cardio on a stair-climbing machine. Before tournaments, she switches to a trainer-designed warm-up that consists of foam rolling followed by muscle activation exercises.

The president’s granddaughter said she’s developed many of her own fitness habits by researching what works and adapting it to fit her lifestyle.

University of Miami commit Kai Trump plays her tee shot on the second hole during The Annika driven by Gainbridge at Pelican on Nov. 13, 2025, at Pelican Golf Club in Belleair, Florida. (Brian Spurlock/Icon Sportswire)

Beyond physical fitness, the golf prodigy said it’s just as important to protect her mental health by taking breaks from phones, spending time with friends and enjoying hobbies.

“I play a lot of golf … and then work out,” she said. “Nothing clears your head better than going to the gym and working out … Even if you’re not lifting heavy or if you’re just walking on the treadmill, being active clears your head and helps your mental health.”

Kai Trump also documents her life on YouTube, where her 1.5 million subscribers follow her experiences as a competitive golfer and member of the Trump family through videos featuring tournaments, travel, family moments and major public events.

Asked for her biggest wellness tip, she said the people you spend time with can have just as much impact as a diet or workout routine.

“If you surround yourself with the wrong people, they can drain you,” she said. “At the end of the day, you are who you surround yourself with.”

Larry Fink and Stephanie Giang, both of Fox News Digital, contributed reporting. 

“At the end of the day, you are who you surround yourself with.” Bing Videos

SUMMATION 

Kai Trump SHUTS DOWN possibility of political future

Kai Trump has revealed how she used her recovery from wrist surgery to transform her fitness routine. The competitive golfer focused on nutrition, strength training, and regular workouts. She also followed a protein-rich diet while avoiding gluten and dairy. Her efforts eventually helped her achieve the six-pack abs she wanted.

Kai Trump shared the diet and workout routine she followed to build six-pack abs after surgery

Kai discussed her fitness journey during a recent interview with Fox News Digital. She said she weighed 120 pounds and consumed 150 grams of protein daily. She also started each morning with approximately 40 grams of protein. Kai typically consumed that amount through a shake or similar breakfast option.

The competitive golfer said she followed a gluten-free and dairy-free diet. She also avoided eggs because of a slight allergy. Kai focused on eating clean foods while including sustainable carbohydrates in her meals. Her favourite dish reportedly featured ground beef, rice, avocado, and seasonings.

Kai said she preferred savoury snacks whenever she wanted something indulgent. Instead of sweets, she reportedly chose prosciutto with pesto. She also said she could happily eat steak or chicken with rice regularly. Her approach emphasised simple meals and consistent protein intake.

Wrist surgery temporarily prevented Kai from playing golf as usual. However, she decided to use her recovery period to focus on fitness. She told friends and family that she had seven months before returning to golf. Kai then set herself a personal goal of developing six-pack abs.

“I literally told them, ‘I have seven months before I return to golf; we’re getting a six-pack,’” she recalled. She said she achieved her goal by prioritising nutritious foods and exercising regularly. Her gym routine included core exercises, squats, and cardio. She also used a stair-climbing machine during her workouts.

Kai said staying active also helped her maintain a positive mindset. She believes exercise can help clear the mind and support mental health. Before tournaments, she follows a trainer-designed warm-up routine. That routine included foam rolling and muscle activation exercises.

TELL US – WERE YOU SURPRISED BY KAI TRUMP’S FITNESS ROUTINE?

WOULD YOU TRY HER PROTEIN-RICH APPROACH TO NUTRITION??

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This Is Where Willie Nelson Lives With His Partner
The Painful Life Story Behind Willie Nelson’s Legendary Career

For decades, Willie Nelson has been one of the most recognizable figures in American music. With his braided hair, bandana, and legendary guitar named Trigger, he became a symbol of outlaw country and artistic freedom.

But behind that calm and easygoing public image lies a life marked by hardship, loss, and personal struggles that many fans never fully understood.

Just Like Waylon Jennings, Willie Nelson is not currently a member of the Grand Ole Opry.

Willie made his Opry debut on November 28, 1964, and was a regular performer for about five years, playing up to 26 shows a year Whiskey Riff. However, in 1969 he moved back to Texas after his home burned down, seeking a more progressive musical environment and a different career path. This decision meant he could no longer make the frequent Nashville trips required for active membership Whiskey Riff.

In 2018, Willie told Texas Standard that it was “just don’t work out that way” to play in Texas on Friday and return to Nashville for Saturday night Opry shows Whiskey Riff+1. He also noted that as his touring schedule grew, he preferred to stay in Texas and play shows in his home state rather than make the long back-and-forth travel. This logistical challenge, combined with his desire to focus on his Texas-based career, led him to rescind his membership Whiskey Riff.

Membership in the Grand Ole Opry is by invitation only and requires a commitment to perform at least 10 times a year in Nashville Country Thang Daily+1. For artists based outside the state, especially in Texas, the travel demands can make it impractical to meet that obligation. Willie’s case is a well-known example of how the Opry’s rules and the artist’s personal circumstances can lead to a star being omitted from the roster.

In short: Willie Nelson was once an Opry member but left the organization in the late 1960s/early 1970s due to scheduling and travel constraints, and he has not rejoined since Whiskey Riff+1.  

Born on April 29, 1933, in Abbott, Texas, Willie Nelson grew up during a difficult time in American history. Raised by his grandparents after his parents separated, Nelson found comfort in music early in life.

Sad Ending Of Willie Nelson Will Disturb You

By the time he was a child, he was already writing songs and performing locally.

That pᴀssion eventually carried him into the music industry, where he would become one of the most influential country artists of all time.

But the road to fame—and the years that followed—were far from smooth.

One of the more unusual stories tied to Nelson’s reputation involves the nickname “SH๏τgun Willie.”

While it later became the тιтle of his famous 1973 album, the name actually came from a dangerous real-life incident.

According to stories shared by Nelson over the years, the nickname originated during a conflict involving his daughter Lana’s former husband. The situation escalated into a violent confrontation when the man reportedly fired sH๏τs at Nelson’s home.

Nelson responded by grabbing a rifle and firing back to drive him away.

Later, when the same man threatened the family again, Nelson reportedly used a sH๏τgun to disable the man’s car by shooting out a tire. Though the story became part of Nelson’s colorful legend, it also reflected the unpredictable challenges that occasionally entered his personal life.

Another source of controversy throughout Nelson’s career has been his outspoken political views.

In a genre often ᴀssociated with conservative politics, Nelson has long embraced progressive causes.

He has openly supported marijuana legalization, environmental activism, and same-Sєx marriage.

His cannabis brand, Willie’s Reserve, even turned his longtime reputation as a marijuana advocate into a legitimate business venture. Still, his political stance sometimes created friction with parts of his fan base.

Willie Nelson Reveals The Real Reason He Wants It To End 

In 2018, Nelson publicly supported Texas politician Beto O’Rourke during a Senate campaign, even inviting him on stage during a concert. Some longtime fans reacted angrily online, but Nelson remained calm, reminding critics that he had never hidden his beliefs and that people were free to agree or disagree.

Yet political controversy was minor compared to one of the greatest crises of his life: his infamous battle with the Internal Revenue Service. In the late 1980s and early 1990s, Nelson faced what became one of the largest tax debts in music history.

Due to failed tax shelter investments arranged by his accounting firm, the IRS determined that he owed an astonishing $32 million in unpaid taxes, penalties, and interest. When he couldn’t pay the debt, the government took drastic action.

In November 1990, federal agents seized many of Nelson’s properties and personal belongings.

They confiscated homes, clothing, awards, and even master recordings of his music.

For a moment, it looked like the legendary musician might lose nearly everything.

One item, however, escaped the raid—his beloved guitar, Trigger.

Nelson’s daughter secretly sent it to Maui before the seizure, preserving the instrument that had become inseparable from his idenтιтy as a musician.

Determined to recover from the financial disaster, Nelson launched creative efforts to repay the debt.

Willie Nelson’s Darkest Day: Country Legend’s Suicide Attempt Revealed

One of the most memorable was an unusual album promoted through television commercials тιтled “The IRS Tapes: Who’ll Buy My Memories?” Part of the profits from the album went directly toward paying off what he owed.

Although the album didn’t sell as strongly as expected, Nelson eventually settled his debts through additional music projects, legal settlements, and years of work.

Financial struggles were only one part of the emotional toll he experienced over the years.

Nelson’s personal life also included multiple marriages and painful divorces.

Life on the road made maintaining relationships extremely difficult, and he openly admitted that constant touring created enormous strain on his marriages.

One dramatic moment occurred in 1971 when his wife Shirley Collie received a hospital bill addressed to Nelson for the birth of a child she had not given birth to.

The bill revealed that Nelson had fathered a daughter with another woman, exposing an affair and ultimately leading to the collapse of the marriage.

Despite the complicated relationships, Nelson often spoke about his former wives without bitterness, once joking that divorces are expensive “because they’re worth it.”

Still, nothing compared to the tragedy that struck Willie Nelson’s family in 1991 – Search

On Christmas Day that year, Nelson’s 33-year-old son Billy was found ᴅᴇᴀᴅ in Tennessee.

Authorities later confirmed that Billy had died by suicide after years of struggling with alcohol addiction.

The loss devastated Nelson.

Friends said he was deeply affected by the tragedy and later described it as the most painful experience of his life.

As the years pᴀssed, additional hardships appeared.

Nelson faced several health challenges, including emphysema and recurring respiratory problems that forced him to cancel concerts on multiple occasions.

He also developed severe carpal tunnel syndrome, a painful condition that affects the hands and wrists—particularly difficult for someone whose career depended on playing guitar.

At one point in 2004, the pain became so intense that Nelson had to stop performing during a concert and undergo surgery, forcing him to cancel months of shows.

Yet through every setback—financial disaster, family tragedy, and physical pain—Willie Nelson continued doing what he loved most: performing music.

Even into his 90s, he remained active on stage, proving that his connection to music was stronger than the hardships he had endured throughout his life.

For fans, that resilience may be the most powerful part of Willie Nelson’s story. Behind the legend is a man who endured extraordinary struggles yet never stopped creating the songs that made him one of country music’s greatest icons.

Willie Nelson “Farm Aid 40”, live from MinneapolisSeptember 20.2025 HUNTINGTON BANK STADIUM

Shania Twain is ‘in charge again’ after facing ‘devastating’ challenges: ‘I had to learn how to be brave’ (exclusive)

Shania Twain Reveals Dark Menopause Weight Loss Battle  

Born Eilleen Regina Edwards in Windsor, Ontario, Twain grew up in poverty and faced abuse at the hands of her stepfather. Music became her refuge, and songwriting, her escape. Shania Twain’s rise to stardom is not just a story of talent.

It’s a story of grit, survival, and unshakable strength.

At 22, just as she was gaining momentum in her music career, tragedy struck. Her mother and stepfather were killed in a car accident, forcing Twain to move home and raise her younger siblings. Many careers would have ended there. Hers was just beginning.

Years later, another personal blow would shake her world. Her husband and longtime producer, Mutt Lange, the man behind her early chart-topping albums, had an affair with Twain’s close friend. The betrayal ended both a marriage and a creative partnership. Still, Twain found a way forward.

Then came another challenge, a diagnosis of Lyme disease, which severely damaged her vocal cords and left her uncertain she would ever sing again. After multiple surgeries and years of vocal therapy, Twain made a remarkable recovery.

In 2017, she released Now, her first studio album in 15 years. It debuted at No. 1 on the Billboard 200, solidifying her comeback. Shania Twain didn’t just return. She reclaimed her place atop the genre she helped redefine. A true Queen of Country Pop, forged through hardship and healed by music.

Shania Twain’s Life Challenges

Shania Twain’s journey from rural poverty to global superstardom has been marked by significant personal and professional challenges.

Childhood poverty and family struggles
Born Eileen Regina Edwards in Windsor, Ontario, Twain was raised in Timmins by her mother Sharon and adoptive father Jerry Twain after her parents divorced when she was two Fox News. The family lived in financial hardship, often going without basic necessities. Her mother struggled with depression, and the home environment was marked by domestic abuse, violence, and instability Fox News+1. Twain recalled being over-responsible for the household, worrying about her parents’ safety, and enduring hunger and poor living conditions HELLO!+1.

Early exposure to music and stage fright
At age eight, Twain began performing in local bars to help support her family, often singing after last call when underage CBS News+1. These early gigs, in smoky, intoxicated environments, left a lasting impression and contributed to her stage fright, which she only overcame in her 50s when she felt confident in her voice and audience CBS News.

Tragic loss of parents
At 22, Twain lost both her mother and stepfather in a car accident, a devastating blow that left her in shock and without a stable foundation American Songwriter+1. She took on the role of caregiver for her younger siblings, putting her music career on hold for years American Songwriter+1.

Shania Twain Honestly Reflects on the ‘Hardest’ Parts of Her Childhood | Us Weekly

Abuse and trauma
Twain has spoken openly about sexual abuse by her stepfather, which she carried silently for years before sharing publicly weverydaystories.com. This trauma, combined with the loss of her parents, shaped her resilience and perspective.

Shania Twain Lyme Disease Recovery – Search

Shania Twain contracted Lyme disease in 2003, which severely affected her voice, and her recovery involved years of medical treatment, vocal therapy, and lifestyle changes.

Diagnosis and Early Symptoms

Shania Twain was bitten by a tick while horseback riding in 2003 during her “Up!” tour, which led to Lyme disease, a tick-borne infection that can affect the joints, heart, and nervous system (ABC News) abcnews.com+1. She experienced severe symptoms including dizziness, blackouts on stage, and loss of balance, which made performing extremely difficult (Woman’s World) Woman’s World. It took several years for doctors to connect these symptoms to Lyme disease, and by the time she was diagnosed, the infection had already caused nerve damage to her vocal cords, resulting in dysphonia and vocal cord paralysis (Today) TODAY.

Treatment Approaches

Twain’s treatment was multifaceted and included both conventional and alternative therapies. Initially, she received antibiotics to address the bacterial infection, which is the standard treatment for Lyme disease (ABC News) abcnews.com. Beyond antibiotics, she explored hyperthermia therapy, which involves exposing the body to high temperatures to target the bacteria, and she also used a range of supplements and nutrients to support her recovery (Biconomy Health) health.biconomy.io.
To regain her vocal abilities, Twain underwent vocal therapy, physical therapy, and even Botox injections in her vocal cords to restore control and strength (Chronic Illness) chronicillness.co. She also had several invasive throat surgeries to repair damage caused by the disease (Today) TODAY. Recovery was slow and required persistence, trial and error, and a willingness to endure multiple interventions over several years.

Lifestyle and Supportive Measures

Twain emphasized the importance of a healthy diet, regular exercise, and stress management in her recovery (Biconomy Health) health.biconomy.io. She prioritized self-care, which she credits as a key factor in regaining her health and vocal abilities. Emotional support from fellow musicians and her own resilience played a significant role in her journey back to performing.

Recovery and Long-Term Effects

After nearly a decade of vocal struggles, Twain made a triumphant return to music with her 2017 album Now, although her voice had changed, carrying more emotion and depth than before (Chronic Illness) chronicillness.co. While she has regained her singing ability, she continues to manage the long-term effects of Lyme disease, including ongoing vocal care and health monitoring (ABC News) abcnews.com. Her case has been studied by specialists as a model for treating neurological vocal disorders and chronic Lyme disease.

Shania Twain releases deeply personal ‘Little Miss Twain’ album

Shania Twain Releases New Single “Dirty Rosie” And Announces New Album – Ireland’s Classic Hits Radio

Lessons from Twain’s Experience

Shania Twain’s journey highlights the importance of early diagnosis, persistence, and a comprehensive treatment approach for Lyme disease. Her story demonstrates that recovery is possible even after severe complications, and it underscores the value of combining medical treatment with lifestyle adjustments, therapy, and emotional support (Chronic Illness) chronicillness.co+1. Twain has also become an advocate for awareness of chronic illness, inspiring others facing similar challenges.

Professional heartbreak
In 2008, Twain discovered her husband, producer Robert “Mutt” Lange, was having an affair with her close friend Marie-Anne Thiébaud HELLO!+1. The betrayal, while painful, was less severe than the grief from her parents’ deaths, but it still triggered a period of emotional reckoning.

Body image struggles
During her 2019 Las Vegas residency, Twain admitted to unhealthy habits to control weight gain, including overworking her body and avoiding mirrors AOL. She later embraced body positivity, especially after navigating menopause, and celebrated her “new body” in her music AOL.

Overcoming adversity
Despite these challenges, Twain’s early experiences—poverty, abuse, loss, and professional setbacks—became the foundation for her music and her ability to connect with audiences. In her 60s, she reflects that “time” has allowed her to finally “get it right” Fox News+1.

In sum, Shania Twain’s life challenges include poverty, abuse, loss of parents, professional betrayal, and body image struggles, but these experiences have also fueled her resilience, artistry, and deep connection with fans.

Shania, 60, did not have an easy life as a kid. She grew up in the picturesque yet impoverished town of Timmins, Ontario, alongside her four siblings. As a young her, Shania remembered her parents’ struggling to make ends meet.

“For so many years, I’ve opened up about some of the difficulties and challenges [of my childhood],” Shania explained on Today with Jenna and Sheinelle. “But I want my fans to relate to the things I talk about when it comes to heartbreak or disappointment.

The singer as a young teen

Sheinelle chimed in, telling Shania: “They do!” Shania’s heartbreak is what makes her music so powerful and connects her with her many fans.

Shania Twain’s difficult childhood

Aside from being raised in poverty, Shania’s stepfather, Jerry Twain, struggled with addiction and mental health issues, often breaking out into violence towards both the singer and her mom, Sharon. 

“I was worried about my father killing my mother,” Shania told The Guardian in 2018. “I thought they’d kill each other. My mom was quite violent, too. Many nights I went to bed thinking: ‘Don’t go to sleep, don’t go to sleep, wait till they are sleeping.’ And I would wake up and make sure everybody was breathing.”

On ‘Little Miss Twain,’ Shania Twain reflects on her humble beginnings and her late mother  

Shania Twain on “Little Miss Twain”

Shania with her parents who tragically died when she was 22

This dark chapter in her life came to a devastating climax when both her parents died in a car crash when she was just 22. Shania recalled her feelings at the time during a 2023 appearance on Today, saying: “I just, you know, I fell apart totally, just into shock for days and I just couldn’t let go of them.”

Shania and Mutt finalized their divorce in 2010, she found solidarity and love with Marie-Anne’s ex-husband Frédéric Thiébaud. The two married on New Year’s Day in 2011 and are still together 15 years later. While she found love, Shania admitted that her divorce was shocking.

“I don’t think that a lot of things that have happened to me since my divorce should have been so hard on me,” Shania reflected on the Armchair Expert podcast in February 2023. “I should have been less naive about life’s ups and downs. Maybe I’m too much, like, ‘That’s all behind me.'”

Shania Twain Reveals Dark Menopause Weight Loss BattleShania Twain – I Ain’t No Quitter (Official Music Video)

Shania Twain’s Life Challenges – Search

Top 10 Shania Twain’s Songs

Happiness, positive emotions, and subjective well-being in dementia – PMC

New Study Shows Positivity Slows Memory Loss

Attitude matters. A new study published in the Psychological Science journal adds more proof that people who tend to be positive, cheerful and enthusiastic experience less memory loss over time.

How the Study Worked

Researchers from Northwestern University’s Life-span Development Laboratory recruited nearly 1,000 people from across the country to participate in a national study to see if general attitude and memory loss were connected. The research team followed the participants, who were middle-aged or older, for nearly 10 years.

At regular checkpoints, the participants were asked to describe their positive emotions over the previously 30 days and take a memory test. The test involved giving the participants a list of words and asking them to recall them immediately and again 15 minutes later. Participants who had a higher level of positive affect had a lower level of memory decline over almost a decade.

The medical term for being upbeat is “positive affect”. It’s the opposite of “negative affect”, which comes from frequent feelings of sadness and anxiousness.

Building on Other Research

According to the Oxford Handbook of Positive Psychology, these additional emotions can contribute to a positive effect:  joviality, self-assurance and attentiveness. The authors also detail how:

• Low levels of positive affect contribute to depression and low satisfaction with work and marriage
• High levels of positive affect contribute to better physical health, including greater immunity to infections

Another study published in The American Psychologist journal showed a relationship between positive affect and flourishing in life. The researchers defined “to flourish” as “to live within an optimal range of human functioning, one that connotes goodness, generativity, growth, and resilience.” They describe the opposite of flourishing as languishing, a hollow or empty feeling that leads to depression and curbs daily activities.

The authors go on to cite a host of other studies that connect positive affect to positive outcomes such as:

• Increased creativity
• More resilience to crisis
• Better recovery from cardiovascular problems
• Less inflammation from stress
• Lower risk of stroke
• Longer life

Take a look at our blog for five more ways to support senior longevity. Sonata Senior Living in Florida offers independent, assisted living and memory care lifestyles in communities designed to promote independence and prevent isolation. We provide activities, events, gourmet dining, wellness programs and life enrichment through music and classes. Our services also include specialized, around-the-clock memory care for Alzheimer’s disease and dementia.

People with dementia often feel profound confusion, frustration, and fear as their brains struggle to process memories, time, and surroundings. This reality can lead to deep feelings of isolation, vulnerability, and anxiety. Because communication becomes difficult, unmet needs or feelings are often expressed through physical and behavioral changes like pacing or agitation. 

The exact experience varies by person and stage, but individuals living with dementia frequently describe or exhibit the following feelings:

• Disorientation and Fear: Everyday environments can suddenly feel unfamiliar or threatening. People may constantly feel “lost” or out of place, even in their own homes.
• Intense Frustration: Being unable to find the right words, complete formerly simple tasks, or make oneself understood is highly exasperating. 
• Loss of Control: Individuals often realize they are losing their independence and struggle with the awareness of their cognitive decline, leading to feelings of sadness or grief. 
• Suspicion and Paranoia: Because memories are distorted or lost, a person with dementia may genuinely feel that items have been stolen or that caregivers have ill intentions simply because they cannot recall where things are. 
• Emotional Amplification: Damage to brain areas that regulate emotion can make a person overreact or experience rapid mood swings. 

Understanding these internal emotions is crucial for providing compassionate care. For strategies, resources, and support networks, you can explore the Alzheimer’s Society or the Alzheimer’s Association.

Unlocking the Potential: The Power of Positivity in Dementia Care

Can a positive outlook protect against dementia? February 28, 2023 Betsy Mills, PhD – Search

Optimism, positivity associated with lower risk of dementia – Penn Memory Center

What Do They Give Dementia Patients To Calm Them Down

Why Do Dementia Patients Get Agitated?

Agitation in individuals with dementia can be linked to physical changes in the brain and can manifest suddenly due to specific triggers like noise or an inability to perform familiar tasks. People with Alzheimer’s disease may exhibit increased agitation or aggression as the condition progresses.

Agitation is characterized by restlessness and worry, with affected individuals unable to settle down. Various factors contribute to this restlessness, including overwhelming environments, frustration with complex tasks, or discomfort from unrecognized pain.

Additionally, changes in surroundings—such as moving to a new residence, hospitalization, or the presence of guests—can induce agitation. Circumstances like loneliness, excessive stimulation, or loss of privacy further exacerbate this behavior. Dementia may hinder a person’s ability to express their feelings, resulting in frustration or outbursts.

Common causes of agitation include fear, fatigue, routine disruptions, perceived threats, changes in caregivers, and physical discomfort. Such behaviors may be a response to disrupted interactions with their environment.

Does Disappointment Calm a Dementia Patient?

Disappointment itself is not a reliable way to calm a dementia patient. In fact, it can often increase agitation or distress because it may trigger frustration, sadness, or confusion — emotions that are already common in people with dementia Dementia Care Central.

Dementia-related emotional unresponsiveness can feel like personal rejection to caregivers, and disappointment can amplify that sense of loss or misunderstanding Psychology Today. When a person with dementia is already struggling to process emotions, disappointment can make them more withdrawn, irritable, or even agitated Dementia UK+1.

Why disappointment can be harmful

• Emotional overload: Dementia patients may not be able to process or regulate disappointment, leading to mood swings or withdrawal Dementia Care Central.
• Confusion about cause: They may not understand why they are upset, which can worsen anxiety or agitation Dementia UK.
• Loss of trust or connection: Repeated disappointment can erode the sense of safety and trust that is so important for emotional well-being Psychology Today.

What actually helps calm a dementia patient

Research and clinical guidance suggest using calming, non-judgmental approaches instead of disappointment:

• Gentle redirection with familiar activities, music, or simple tasks aliyahealthcare.com.
• Soothing touch and a calm, low voice to reduce agitation aliyahealthcare.com.
• Addressing physical needs like hunger, thirst, or pain, which can be mistaken for emotional distress Senior Safety Advice.
• Maintaining a familiar environment to reduce confusion and anxiety Dementia UK.
• Using positive, reassuring language and avoiding criticism or negative comments Senior Safety Advice.

Bottom line

Disappointment is not a calming strategy for dementia patients. Instead, focus on reducing triggers, meeting their needs, and using empathetic, supportive communication. This approach is more likely to help them feel safe, understood, and calm.

3 Tools to Heal the Pain of Dementia’s Emotional Disconnect

Learn to recognize, navigate, and heal emotional wounds of caregiving.

Posted June 11, 2025 |  Reviewed by Monica Vilhauer Ph.D.

Key points

• Recognizing dementia-related emotional disconnect as normal helps caregivers reduce self-blame and shame.
• Identifying your emotional stage in response to emotional unresponsiveness provides relief and clarity.
• Understanding dementia relationship dissonance transforms challenges into opportunities for healing.
• Simple empathy reframing and self-care rituals can dramatically reduce emotional distress in caregiving.

“I just feel so unloved,” shared a participant in our recent study, reflecting on the deep pain she experienced when her mother—once her best friend—could no longer celebrate her joys or respond to important moments in her life due to dementia.

If you’re caring for someone with dementia, you likely know this pain intimately. But that gut-wrenching feeling isn’t just heartbreak—it signals something deeper. In a recent study published in Aging & Mental Health, my team and I uncovered how dementia’s emotional unresponsiveness can feel like personal rejection, deeply eroding self-esteem and undermining relationships we’ve cherished our entire lives.

Because our earliest relationships shape our deepest sense of safety and worth, feeling ignored—even by someone whose behavior we rationally understand as dementia-related—can trigger ancient, preverbal fears of rejection and abandonment.

Below are three practical, therapeutic tools distilled from our research. These approaches can help caregivers and clinicians alike name, navigate, and heal from what I’ve termed “dementia relationship dissonance.”

1. Name the Invisible Wound: Dementia Relationship Dissonance

Most dementia conversations revolve around practical caregiving tasks—medication, safety, and daily care. Yet, what happens emotionally when someone we love no longer seems able to “tune in” to us?

Our participants described dementia unresponsiveness as more than forgetfulness—it felt profoundly personal, painful, even traumatizing. To acknowledge and validate this emotional pain, I created the term Dementia Relationship Dissonance:

The deep emotional hurt caused by feeling unseen or ignored by a loved one due to dementia symptoms. This creates feelings of misunderstanding, and missed connection.

Why It Matters:

• Naming this hurt as dementia relationship dissonance allows you to recognize that your pain isn’t a personal failing. It’s a shared, recognized phenomenon—freeing you from guilt and shame.
• Introducing this terminology validates our experiences, helping us articulate grief (yes, you can grieve something that still has physical presence!) and understand reactions as completely natural.

Simple Therapeutic Step:

When you feel ignored or unseen, remind yourself:

“This is dementia relationship dissonance—this gap is caused by dementia, not by me. My feelings are valid because I’m actually wired to see myself through the eyes of others who I love. I will get through this.”

2. Map the Emotional Journey: A Clear 3-Stage Model

Understanding exactly where you are emotionally can bring clarity and comfort. Here’s the emotional roadmap our study participants revealed:

Stage 1: Shock & Pain – The immediate sting of feeling invisible or ignored.

Stage 2: Coping Reactions – Typical responses: withdrawal, attempts at extreme empathy, or seeking outside support.

Stage 3: Interpretation – The most distressing interpretations included questioning self-worth. Painful internal narratives like, “If they don’t recognize me, do I even matter?”

Why It Matters:

• Recognizing your stage helps you or your clients understand exactly what emotional support or coping strategy is needed right now.

Simple Therapeutic Step:

Create a quick checklist or use a journal to identify your current stage after difficult interactions:

• Am I feeling raw, immediate pain? Am I re-living the pain over and over?
• Am I reacting by withdrawing or overly empathizing?
• Am I questioning my value?

Identifying your stage points clearly to your next healthy step—grounding exercises, self-care strategies, or reconnecting with your worth outside caregiving.

3. Concrete Strategies to Reconnect and Heal

From our interviews, caregivers repeatedly highlighted four simple, powerful coping strategies:

A. Empathy-Reframing: Instead of personalizing unresponsiveness (“They’re ignoring me”), reframe it as, “They’re in a different world right now.” Some caregivers successfully connected by joining loved ones in memories or activities from their reality—like singing old songs together.

B. Healthy Boundary-Setting: It’s okay—and often essential—to limit your interactions when feeling emotionally overwhelmed. Recognize it’s healthy self-care, not selfishness, to step away for a brief reset.

C. Daily Self-Care Rituals: Establish small rituals post-visit. A caregiver favorite: Take five minutes afterward to write down one positive self-reflection (“I’m patient,” “I’m kind,” “I’m resilient”).

D. Self-Image Repair: When feeling hurt or rejected, consciously remind yourself of three personal qualities unrelated to caregiving (e.g., loyal friend, talented cook, dedicated professional).

Why It Matters:

• Concrete actions reduce feelings of helplessness, turning emotional distress into manageable moments of healing.

Simple Therapeutic Step:

At the end of each interaction or therapy session, practice this brief reflective exercise:

“What did I learn or appreciate about myself today?”

Write it down and keep these affirmations handy for difficult moments.

Why This Perspective Matters Now

More than 10 million families face dementia each year. While practical caregiving advice is plentiful, the emotional wounds—particularly those related to feeling unseen—often remain hidden and unresolved.

By understanding dementia relationship dissonance, mapping emotional stages, and adopting practical coping strategies, we empower caregivers and clinicians to transform silent heartbreak into visible paths of healing.

Lauren Daigle – Be Okay / Hold On To Me | Live Performances | GMA Dove Awards

The Incredible Power of Positivity in Alzheimer’s Disease | Meet Dangle and Dot

Lauren Daigle – Your Grace Still Finds Me | Deep Worship for Prayer & Healing

32 Therapeutic Activities for Patients with Dementia

Dementia and Positive Energy’ – Search Videos

Inside Canada’s first dementia village

Dementia and positive energy – Google Search

My Stage 4 Pancreatic Cancer Journey | How I Found Out & How It Changed My Life

1. Survivors of stage 4 pancreatic cancer often share inspiring stories of resilience, treatment journeys, and the importance of support systems.Personal Survivor StoryOne notable survivor, Marisa Harris, was diagnosed with stage IV pancreatic cancer and faced a daunting prognosis. Initially, she was advised that chemotherapy would only provide a few extra months of life.
2. However, she chose to explore alternative treatments alongside chemotherapy, including dietary changes, supplements, and exercise. Despite the challenges, her tumor markers improved, and she became a long-term survivor. Marisa’s story highlights the power of personal determination and the impact of a supportive healthcare team letswinpc.org.
3. General Insights on Survival
   • Survival Rates: The five-year survival rate for stage 4 pancreatic cancer is low, typically around 3% to 5%. However, individual experiences can vary significantly, and some patients have exceeded expectations acibademhealthpoint.com.
4. • Treatment Options: While stage 4 pancreatic cancer is considered advanced and often incurable, treatments such as chemotherapy, targeted therapy, and palliative care can help manage symptoms and improve quality of life.
5. • Support Systems: Emotional and psychological support from family, friends, and support groups plays a crucial role in the journey of cancer survivors. Many survivors emphasize the importance of having a strong support network to navigate the challenges of their diagnosis.
   ConclusionWhile stage 4 pancreatic cancer presents significant challenges, stories of survivors like Marisa Harris serve as a reminder of the resilience of the human spirit. Each survivor’s journey is unique, and advancements in treatment and supportive care continue to provide hope for improved outcomes and quality of life for those affected by this disease.
6. Faith, Hope, Perseverance, Stage IV – Let’s Win Pancreatic CancerFaith, Hope, Perseverance, Stage IV – Let’s Win Pancreatic Cancer
7. Just before his 41st birthday, Dan, a lawyer from Cleveland, experienced a pain in his legs that led to a stage 4 pancreatic cancer diagnosis. Today, Dan is 45 years old, in complete remission and treatment-free.Dan sat down for an interview with  From Stage 4 to Survivor: Dan’s Pancreatic Cancer Journey | CURE  in which he shared his story. During the discussion, he shared the moment he learned of his diagnosis, and how he ultimately decided to participate in clinical trials for his pancreatic cancer treatment. He also offers his insights into life-changing medical choices, as well as the importance of advocating for oneself as a patient undergoing cancer treatment.  From Stage 4 to Survivor: Dan’s Pancreatic Cancer Journey | CURE
8.  CURE, in which he shared his story. During the discussion, he shared the moment he learned of his diagnosis, and how he ultimately decided to participate in clinical trials for his pancreatic cancer treatment. He also offers his insights into life-changing medical choices, as well as the importance of advocating for oneself as a patient undergoing cancer treatment.Just before his 41st birthday, Dan, a lawyer from Cleveland, experienced a pain in his legs that led to a stage 4 pancreatic cancer diagnosis. Today, Dan is 45 years old, in complete remission and treatment-free.
9. How did you decide to participate in a clinical trial, and what influenced your decision to pursue an experimental treatment?I did two clinical trials. The first one was an immunotherapy and a PARP inhibitor. I did Keytruda (pembrolizumab) and Lynparza (olaparib) for about two years, and then the second one was an early-stage trial.
10. Both of them were through Memorial Sloan Kettering Cancer Center.I knew both from the knowledge within my family and through conversations with my treating doctors at the clinic that chemotherapy was only going to work for so long, or my body would only be able to tolerate chemotherapy for so long. That was not an end state. That was the first step of hopefully at least a few steps.
11. Once we got settled back in Cleveland, once I started chemotherapy, and once I was settled into that routine, we started asking questions of my oncologist at the Cleveland Clinic: what trials was the clinic involved in? What options and opportunities did they see for me?
12. We had those conversations within the Cleveland Clinic world, and then my family began looking through clinicaltrials.gov. They were comfortable enough with the vocabulary and everything else to pinpoint options based on the genetic markers I had, the stage of the disease (which was stage 4) and the fact that my tumors were responding to chemotherapy. They were able to identify different hospitals and groups around the country engaged in pancreatic cancer trials that I might eventually be eligible for.About halfway through my chemotherapy, they started sending messages, saying, “Hey, you guys are running these trials. We’d like more information.
13. Could we get a secondary consultation with you?” We went through the whole clinic onboarding process, the insurance process, and ended up having consults with both the MSK team and the MD Anderson team. Through that, little by little, we got more information on what I would be eligible for, and we ended up making decisions about which paths to pursue.The important thing about that — there are a couple of things. Number one: patients need to advocate for themselves. They need to ask questions as early as possible: “Is this working? What’s next? What can I do next?
14. How can I find out what to do next?” If that involves seeing other doctors, no doctor should be upset that you’re seeking additional opinions. It’s strange, patients facing something as difficult as stage 4 pancreatic cancer won’t necessarily want to let their doctor know they’re seeing another doctor, or they might not want to ask about other doctors because they don’t want to be impolite, hurt someone’s feelings, or think the doctor will get annoyed. Any doctor I’ve met does not think that way.Patients need to feel comfortable asking for secondary consults, other opinions, and additional opportunities. Not every oncologist has all the information.
15. Different people are doing different things at different times, and treating oncologists aren’t necessarily the same people conducting the trials. The more information you can get, the more questions you can ask, and the more conversations you can have, the higher the possibility you will uncover opportunities your treating oncologists didn’t know existed.Outside of conversations with your doctor, if you can figure out how to use clinicaltrials.gov, that is a great resource. It’s not very user-friendly, and the vocabulary can be difficult, but ChatGPT plus clinicaltrials.gov can help identify potential trials you can then discuss with doctors who might have other opportunities.
16. I would really encourage people to do both of those things to the extent they can.How did you decide to participate in a clinical trial, and what influenced your decision to pursue an experimental treatment?I did two clinical trials. The first one was an immunotherapy and a PARP inhibitor. I did Keytruda (pembrolizumab) and Lynparza (olaparib) for about two years, and then the second one was an early-stage trial. Both of them were through Memorial Sloan Kettering Cancer Center.
17. I knew both from the knowledge within my family and through conversations with my treating doctors at the clinic that chemotherapy was only going to work for so long, or my body would only be able to tolerate chemotherapy for so long. That was not an end state. That was the first step of hopefully at least a few steps.Once we got settled back in Cleveland, once I started chemotherapy, and once I was settled into that routine, we started asking questions of my oncologist at the Cleveland Clinic: what trials was the clinic involved in?
18. What options and opportunities did they see for me? We had those conversations within the Cleveland Clinic world, and then my family began looking through clinicaltrials.gov. They were comfortable enough with the vocabulary and everything else to pinpoint options based on the genetic markers I had, the stage of the disease (which was stage 4) and the fact that my tumors were responding to chemotherapy. They were able to identify different hospitals and groups around the country engaged in pancreatic cancer trials that I might eventually be eligible for.About halfway through my chemotherapy, they started sending messages, saying, “Hey, you guys are running these trials. We’d like more information. Could we get a secondary consultation with you?”
19. We went through the whole clinic onboarding process, the insurance process, and ended up having consults with both the MSK team and the MD Anderson team. Through that, little by little, we got more information on what I would be eligible for, and we ended up making decisions about which paths to pursue.
20. The important thing about that — there are a couple of things. Number one: patients need to advocate for themselves. They need to ask questions as early as possible: “Is this working? What’s next? What can I do next?
21. How can I find out what to do next?” If that involves seeing other doctors, no doctor should be upset that you’re seeking additional opinions. It’s strange, patients facing something as difficult as stage 4 pancreatic cancer won’t necessarily want to let their doctor know they’re seeing another doctor, or they might not want to ask about other doctors because they don’t want to be impolite, hurt someone’s feelings, or think the doctor will get annoyed. Any doctor I’ve met does not think that way.
22. Patients need to feel comfortable asking for secondary consults, other opinions, and additional opportunities. Not every oncologist has all the information. Different people are doing different things at different times, and treating oncologists aren’t necessarily the same people conducting the trials. The more information you can get, the more questions you can ask, and the more conversations you can have, the higher the possibility you will uncover opportunities your treating oncologists didn’t know existed.
23. Outside of conversations with your doctor, if you can figure out how to use clinicaltrials.gov, that is a great resource. It’s not very user-friendly, and the vocabulary can be difficult, but ChatGPT plus clinicaltrials.gov can help identify potential trials you can then discuss with doctors who might have other opportunities. I would really encourage people to do both of those things to the extent they can.
24. Faith, Hope, Perseverance, Stage IV – Let’s Win Pancreatic Cancer Faith, Hope, Perseverance, Stage IV – Let’s Win Pancreatic Cancer Stage 4 Pancreatic Cancer Survivor – Search Images

Lauren Daigle first auditioned for ‘American Idol’ in its ninth season. | Fox/Fox

Before she was famous, Daigle actually was part of the process on three separate seasons of Idol as an auditionee or contestant, then two more once she had made it as a Christian singer-songwriter on her own.

Her first appearance on the show came when she was 18 in 2010 (Season 9), when she missed out to the top 24. She then tried out the following year and did not make it to Hollywood. Her third time as a contestant was in 2012, when she was cut from the show in the Las Vegas round.

Speaking to Cosmopolitan, she said these rejections were what spurred her on to the career she has had since. She said: “I remember thinking, ‘My whole plan has just flipped upside down…’ I knew right then, sitting in that moment, I’m going to have to decide whether I’m going to get back up and start trying or if I’m gonna let that just determine the course of my life.”


Lauren Daigle American idol
Lauren Daigle first auditioned for ‘American Idol’ in its ninth season. | Fox/Fox
She then moved to Baton Rouge for college, and sang for a band. This led to her getting background vocal work, being invited to an artist retreat and getting signed by a label after they heard her sing.

Daigle said of this to Cosmo: “It’s so beautiful and powerful to see where a ‘no’ can take you. I would tell younger Lauren, ‘Just hang tight. Ride the wave. Let the journey unfold before you as it’s supposed to and you’ll be right where you’re supposed to be.'”

Since then, Daigle has had three number one albums and four number one singles on the Christian charts. She has also won two Grammys, five Billboard Music Awards and two American Music Awards.


In 2019, she returned to Idol for its 17th season. This time, however, she was back as a guest mentor for the top six. She also performed on the finale of Season 18, alongside that night’s winner Just Sam.

Daigle is part of an illustrious list of stars who went on to find fame on their own after failing to make it on American Idol. Among those also rejected from the show were Lady A lead singer Hillary Scott, who auditioned twice, the late Naya Rivera, who used the same audition song for Glee, and Colbie Caillat, who auditioned with her future hit “Bubbly.”

Teenager’s Health Crisis: The Cytomegalovirus Diagnosis

At the age of 15, Lauren Daigle was on a typical high-school path until it was abruptly altered by a serious health diagnosis. She contracted cytomegalovirus (CMV), a common virus that, in her case, caused a debilitating autoimmune response.

This condition required her to be isolated and homebound for two years to protect her weakened immune system. Instead of attending classes and social events with her peers, Daigle was confined to her home, facing not only physical limitations but also the mental and emotional toll of isolation. This period was a significant test of her resilience, forcing her to find strength and purpose in a new way.

What is Cytomegalovirus (CMV)?

Cytomegalovirus, or CMV, is a very common virus belonging to the herpes family, and most people are infected with it at some point in their lives, often without any symptoms. However, for those with weakened immune systems, CMV can cause serious health problems. It is related to the viruses that cause chickenpox and infectious mononucleosis. In cases like Daigle’s, it can trigger a significant autoimmune reaction, forcing the body to fight a battle that leaves it physically drained and highly vulnerable. This is why isolation was necessary for her during her recovery.

The Unexpected Silver Lining: Music as Healing

Forced to stay home and isolated, Daigle’s mother sought a way to combat the depression and loneliness her daughter was experiencing. She enrolled Lauren in voice lessons. What began as a creative outlet quickly transformed into something more profound. For Daigle, singing became her “healing” and a source of purpose during her confinement. This period of intense focus on music was an incubation period for her artistry, helping her discover her true passion and setting her on the path to becoming the Grammy-winning musician she is today.

Launching a Career from a Space of Isolation

The experience taught her deep lessons about resilience and hope. She recalled having visions of her future as a performer even while confined to her home, seeing “stages and people in the crowd”. The isolation and struggle ultimately provided the raw material for her songwriting, infusing her music with a profound sense of purpose and vulnerability that resonates with millions. As she has stated, she could “live a lifetime off of just those two years” of experience. The challenges she faced as a teenager became the launchpad for her successful career, proving that even the darkest moments can contain the seeds of future success.

Later Health and Mental Wellness Struggles

Decades after her battle with CMV, Daigle faced another significant health challenge, this time related to mental wellness. In 2023, following a COVID-19 infection, she experienced debilitating post-COVID symptoms, including panic attacks and anxiety. This period, she noted, felt like a new “rock bottom,” also causing her to confront a different kind of inner struggle. She sought counseling and leaned on her faith, family, and friends to get through it, once again using her personal pain to create meaningful art, like her song “Thank God I Do”. Her openness about these struggles has helped to destigmatize mental health challenges within the Christian music community and beyond.

Comparing Daigle’s Health Battles: Teen Illness vs. Adult Mental Health

Trigger	Debilitating autoimmune response to CMV infection.	Post-COVID symptoms combined with pandemic-related turmoil.
Duration	Roughly two years of being homebound.	Described as an intense period of struggle following COVID-19 infection.
Primary Symptoms	Weakened immune system, isolation, and eventual depression.	Panic attacks, anxiety, and a feeling of “rock bottom”.
Impact on Career	Fueled her passion for music and set her career path.	Inspired new music, including the hit “Thank God I Do”.
Recovery Method	Voice lessons and creative expression as a coping mechanism.	Counseling, support from family, and channeling pain into music.

Lauren Daigle Opens Up About Overcoming Loneliness & Finding Purpose Emotional Interview @WGTS919fm

The Aftermath: A Testament to Resilience

Lauren Daigle’s story is a powerful testament to the idea that adversity can be a catalyst for growth. The two years she spent in isolation due to cytomegalovirus were a turning point, not an end point. Her experiences with both physical and mental health challenges have provided a wellspring of inspiration, informing her musical message of hope and perseverance.

Instead of being defined by her diagnoses, she used them as launchpads, forging a deeper connection with her faith and her purpose. Her candidness about her struggles has made her an even more relatable figure for fans who have faced their own difficult journeys.

This journey is a clear example of how turning inward during times of physical weakness can lead to immense personal and creative strength. For more information on cytomegalovirus, you can review this detailed overview from Yale Medicine. It is interesting to note the different ways the body and mind can be affected by illness at different stages of life.

Lauren Daigle American Idol: Her Powerful Rise From “No”

42 Facts About Lauren Daigle – Facts.net

Did Lauren Daigle Win American Idol – Search

Lauren Daigle never won American Idol. She auditioned three times between 2010 and 2012 (Seasons 9, 10, and 11) but was eliminated each time, making it to Hollywood in only one of those seasons Showbiz Cheat Sheet+2.

In Season 9 (2010), she reached the Top 46 but was cut before the Top 24. In Season 10 (2011), she didn’t make it to Hollywood. In Season 11 (2012), she made it to Las Vegas but was eliminated before the live shows americanidol.fandom.com.

Despite not winning, Daigle went on to become one of the most successful Contemporary Christian music artists, with multiple Grammy Awards, Billboard Music Awards, and a strong fan base americanidol.fandom.com+1. She has also returned to the Idol stage as a mentor and performer, but her Idol career never included a title win.

In Conclusion

In summary, Lauren Daigle’s well-documented health challenges include a teenage diagnosis of cytomegalovirus, which forced her into a two-year period of isolation and led her to discover her musical passion. Later, she openly discussed experiencing panic attacks and anxiety following a COVID-19 infection, which also influenced her art.

Her story highlights how overcoming illness and mental health struggles can lead to profound artistic and personal growth. Through her journey, she has demonstrated how resilience can transform hardship into a source of immense strength and creativity, ultimately inspiring her music and her audience.

Lauren Daigle and Friends Show

Lauren Daigle Opens Up About Faith, Illness & Finding Her Voice in God | Lent Pray40

Grammy Award-winning singer and songwriter ‪@laurendaiglemusic‬ sits down with Jeff Cavins for a deeply personal conversation about growing up in Louisiana, the illness that first drew her close to Jesus, and the way music has become her greatest form of prayer.

In this moving conversation, Lauren opens up about: 01:01 Growing up in Louisiana and the culture that shaped her faith 02:19 The autoimmune illness at 15 that transformed her relationship with Jesus 03:06 How God began showing her visions of stages and arenas before her career began 04:31 Writing “Let It Be Hallelujah” and losing her co-writer to a brain tumor during the process 06:47 How music gives language to prayers people can’t yet find words for 12:24 Pulling over in New Orleans and asking God what labeling had done to her voice .

What Happened to Lauren Daigle? A Discernment Deep-Dive

In this full-length discernment deep-dive, we explore the powerful rise—and controversial shifts—of one of Christian music’s biggest names. From “You Say” to The Ellen Show, Lauren Daigle captured hearts with her voice and message… but in recent years, many believers have asked:

Has her message changed?

Why did she stop clearly naming Jesus in her music and interviews?

Is she still representing the gospel, or has she drifted into cultural compromise? This video unpacks it all—her lyrics, her interviews, her image, and her mission—through a biblical lens. WITH No drama. No gossip. Just honest, prayerful Christian discernment. RISE UP!!!!!!

Lauren Daigle Leads 1,000+ Inmates in Worship at Angola Prison | @Lauren Daigle

Lauren Daigle at Stanford Frost Amphitheater 08/29/24

Lauren Daigle, LIVE, at @RODEOHOUSTON 2025

K-LOVE Cruise 2026 (Day 1) – Lauren Daigle concert

#laurendaigle #klovecruise Set List: 00:00 Intro 00:20 These Are The Days 05:35 New 10:15 Look Up Child 13:50 Trust In You 18:00 Lauren Daigle talks to audience 20:21 Let It Be A Hallelujah 24:20 Lauren Daigle talks to audience again 28:34 Desperate (with Jamie MacDonald) 32:24 Rescue 36:13 Thank God I Do 39:01 O’Lord 43:08 Still Rolling Stones 47:01 You Say 52:35 How Can It Be (Outro)

The Role of Biblical Nutrition in the Fight Against Cancer (Part 1) | Dr. Josh Axe at TTAC […] – Search

The Role of Biblical Nutrition in the Fight Against Cancer (Part 2) | – Search

Dr Josh Axe grew up in Troy, Ohio, on August 18, 1981 en.everybodywiki.com+1. He grew up in the small city, where he played soccer as a child en.everybodywiki.com. His early life in Troy was shaped by his parents’ backgrounds: his father worked on power lines for Ohio Bell (later AT&T) and was a semi-professional water skier, while his mother was an elementary school gym and swim teacher who prioritized her children’s education Houston Axe.

A defining moment came during his teenage years when his mother was diagnosed with stage IV breast cancer and given a 40% chance of survival. Although her cancer eventually went into remission, the experience deeply influenced his passion for using natural methods to help others Houston Axe.

Josh Axe later attended the University of Kentucky, where he competed on the triathlon team that won national championships, and went on to earn a Doctor of Chiropractic degree from Palmer College of Chiropractic, a Doctor of Natural Medicine, and a Certified Nutrition Specialist credential Houston Axe.

Today, he is best known as a doctor of natural medicine, chiropractor, and entrepreneur, with a career spanning functional medicine, media, and natural health products en.everybodywiki.com+1.

Dr. Josh Axe’s “How My Mom Reversed Cancer Naturally (After Chemo Failed)”

In a widely shared episode of The Dr. Josh Axe Show, Dr. Axe shares the story of his mother, Tammy Peterson, who faced an aggressive cancer diagnosis after conventional chemotherapy failed. He describes how she went on to reverse her cancer using a combination of natural, holistic, and faith-based therapies thehealthinstitute.com.    

Key Points from the Episode

• Root causes of cancer: Dr. Axe emphasizes that only 5–10% of cancers are inherited; the rest are largely driven by diet, toxins, metabolism, and lifestyle YouTube+1.
• Therapies used:
  • Fasting to reset metabolism and reduce cancer cell growth.
  • Ketogenic diet to shift the body’s fuel source and create an environment less favorable to cancer cells.
  • Oxygen therapies to improve cellular oxygenation and support immune function.
  • Top anti-cancer herbs and supplements such as curcumin, green tea extract, and other phytochemicals thehealthinstitute.com.
• Diet and nutrition: Focus on whole, plant-based foods, anti-inflammatory ingredients, and avoiding processed foods and toxins thehealthinstitute.com.
• Emotional and spiritual healing: Dr. Axe highlights the importance of faith, prayer, and emotional well-being as part of the recovery process thehealthinstitute.com.

What “Before and After” Looks Like

While Dr. Axe doesn’t provide clinical lab results, the episode frames the “before” as a stage of aggressive cancer post-chemo, and the “after” as a reversal of symptoms and disease through natural interventions. He presents this as a case study to inspire hope and encourage exploring complementary and alternative cancer treatments alongside conventional care.

Important Context

• This is a personal story and not a medical guarantee.
• Dr. Axe’s approach is part of his holistic, integrative health philosophy, which complements but does not replace standard oncology treatment.
• Always consult with a qualified healthcare provider before making changes to cancer treatment plans.

If you want to watch the full episode, it’s available on Dr. Josh Axe’s YouTube channel and The Health Institute’s blog, where he walks through the science, strategies, and spiritual aspects of his mom’s recovery YouTube+1.

How My Mom Reversed Cancer Naturally (After Chemo Failed)

Mrs. Axe Tells Her Story
Only 5–10% of cancers are inherited. The rest? Largely driven by diet, toxins, metabolism, and lifestyle. In this powerful episode, Dr. Josh Axe unpacks the real root causes of cancer and shares miraculous healing stories—including his mom, Tammy Peterson, Jordan Rubin, and others who beat the odds with natural and faith-based therapies.

Discover the science, strategies, and spiritual truths that challenge the conventional cancer narrative.

You’ll Learn:

What really causes cancer (hint: it’s not just DNA)
How fasting, keto, and oxygen therapies helped reverse aggressive diagnoses
The best diets for fighting and preventing cancer
Top anti-cancer herbs, supplements, and therapies
Why faith and emotional healing are crucial to recovery
This episode will open your eyes to the healing potential of holistic medicine, metabolic science, and spiritual hope. Whether you’re facing illness or want to prevent it, you’ll walk away empowered and equipped.

#cancer #naturalhealth #draxe

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00:00 Backstory of Josh’s Mom

05:16 Patients Who Have Reversed Cancer

06:45 What Really Causes Cancer

15:02 Traditional Chinese Medicine Perspective on Cancer

16:39 Best Cancer-Fighting Diets

36:21 Best Cancer-Fighting Foods

40:18 Top Cancer-Killing Herbs

46:48 Cancer-Fighting Supplements

50:21 Advanced Therapies for Cancer Prevention & Recovery

1:00:32 Importance of Spirituality & Prayer in Healing Journey

CHOIR! of 2500 sings “ANGEL” with Sarah McLachlan

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Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel.

Follow Dr. Josh Axe dr josh axe youtube – Search

Instagram https://www.instagram.com/drjoshaxe/

Twitter https://x.com/drjoshaxe

Facebook https://www.facebook.com/DrJoshAxe/

TikTok https://www.tiktok.com/@drjoshaxeshow

Website https://draxe.com/

——

Staying healthy in today’s world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually.

Every Wednesday, you’ll get:

Holistic health news & life-hacks from a biblical worldview
Powerful free resources including classes, Q&As, and guides from Dr. Axe
The latest episodes of The Dr. Josh Axe Show
Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe
Source:  How My Mom Reversed Cancer Naturally (After Chemo Failed) – The Health Institute

How My Mother Survived Stage-4 Breast Cancer: An Excerpt from Dr. Josh
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Links:

https://www.cancerresearchuk.org/about-cancer/treatment/complementary-alternative-therapies/individual-therapies/budwig-diet

https://journals.lww.com/eurjcancerprev/abstract/9900/the_effects_of_the_ketogenic_diet_on_cancer.175.aspx
https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet

https://www.sciencedirect.com/science/article/abs/pii/S0304419X20302134?via%3Dihub

https://www.sciencedirect.com/science/article/abs/pii/S1040842819300885?via%3Dihub

https://www.tandfonline.com/doi/10.1080/01635581.2023.2274135?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21818
https://link.springer.com/article/10.1007/s11095-008-9661-9

Dietitians reveal 5 grocery stores they trust for quality

https://pmc.ncbi.nlm.nih.gov/articles/PMC10183216

https://pmc.ncbi.nlm.nih.gov/articles/PMC9530862

https://pmc.ncbi.nlm.nih.gov/articles/PMC9750928

https://pmc.ncbi.nlm.nih.gov/articles/PMC7793079

https://pmc.ncbi.nlm.nih.gov/articles/PMC4618242

https://pmc.ncbi.nlm.nih.gov/articles/PMC9278815

https://www.ncbi.nlm.nih.gov/books/NBK65971

https://www.mdpi.com/1422-0067/23/18/10502
https://pubmed.ncbi.nlm.nih.gov/24403443/
https://pubmed.ncbi.nlm.nih.gov/20361473/

https://www.mdpi.com/2075-4426/14/9/929

https://pubmed.ncbi.nlm.nih.gov/35334103/
https://pubmed.ncbi.nlm.nih.gov/37054849/
https://pubmed.ncbi.nlm.nih.gov/35457200/
https://pubmed.ncbi.nlm.nih.gov/32211937/
https://pubmed.ncbi.nlm.nih.gov/36674232/
https://pubmed.ncbi.nlm.nih.gov/34103583/
https://pubmed.ncbi.nlm.nih.gov/38473720/

https://www.mdpi.com/1467-3045/43/2/42

Dr axe mom before and after chemotherapy