
1925 portrait of 18 year old Maria Branyas. Credit: Wikimedia Commons
What Scientists Found Inside a 117-Year-Old Woman Reveals New Clues to Long Life
The findings, published in Cell Reports Medicine, suggest that extreme longevity arises from the interplay between genetic and environmental factors, offering insights into the mechanisms of healthy aging.
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Born in 1907, M116 was the world’s oldest verified living person until her death in 2024 at 117 years and 168 days. An analysis of M116’s biology now reveals that her record-breaking longevity was due to a combination of protective genetics, a healthy gut microbiota, efficient metabolism, and low inflammation.
“In Catalonia, the historic nation where M116 lived, the life expectancy for women is 86 years, so she exceeded the average by more than 30 years,” the authors say. Though more people now live past 100, reaching beyond 110 is still extremely rare, and scientists don’t know why people such as M116 achieve such extraordinary longevity.
To uncover some clues, Eloy Santos-Pujol at the Central University of Catalonia in Barcelona, Spain, and his colleagues examined M116’s blood, DNA, metabolism, immune system, microbiota, and epigenetic marks—chemical tags on the DNA that regulate gene expression.
Protective biology
M116’s chromosomes looked normal but her telomeres—the protective caps on DNA that shorten with age—were unusually short. Her genome contained some rare genetic variants that might explain her longevity. These were linked to healthy immune responses, heart function and brain protection.
M116’s mitochondria—the cell’s powerhouses—worked better than those in younger women, and her immune system showed unique characteristics that promoted low inflammation levels. She also had one of the healthiest cholesterol profiles ever recorded, the researchers found.
Although she had some of the typical age-related changes, her cells showed protective epigenetic marks at certain DNA regions, which may have helped prevent disease.
Extreme longevity
M116’s microbiota was unusually diverse and rich in Bifidobacterium—a beneficial gut microbe that usually declines with age. Bifidobacterium has been shown to help fight inflammation and support healthy fats. At the same time, she had few harmful bacteria linked to frailty and inflammation.
The abundance of Bifidobacterium may explain M116’s excellent cholesterol profile and low inflammation levels, the researchers say. Her healthy microbiota, they add, may have been boosted by a Mediterranean diet and daily yogurt, which encourage Bifidobacterium to grow.
“The picture that emerges from our study, although derived only from this one exceptional individual, shows that extremely advanced age and poor health are not intrinsically linked and that both processes can be distinguished and dissected at the molecular level.”
What is already known
Born in 1907, M116 was the world’s oldest verified living person until her death in 2024 at 117 years and 168 days. Though more people now live past 100, reaching beyond 110 is still extremely rare, and scientists don’t know why people such as M116 achieve such extraordinary longevity.
What this research adds
Researchers examined M116’s blood, DNA, metabolism, immune system, microbiota, and epigenetics. They found protective genetic variants, strong mitochondrial and immune function, efficient cholesterol and fat metabolism, and very low inflammation. Her gut microbiota was unusually diverse and rich in Bifidobacterium—a beneficial gut microbe that usually declines with age.
Conclusions
The findings indicate that M116 long life came from a combination of protective genetics, a healthy gut microbiota, efficient metabolism, and low inflammation. They also suggest that extreme longevity arises from the interplay between genetic and environmental factors, offering insights into the mechanisms of healthy aging.
BONUS: I’ve Had 2 Near-Death Experiences. Here’s What I Saw When I Died.
A remarkable new study of the world’s oldest verified living person reveals a surprising picture of extreme longevity.
Maria Branyas Morera was an American-born Spanish supercentenarian and the world’s oldest verified living person from January 17, 2023, until her death on August 19, 2024, at 117 years and 168 days.
Born in San Francisco on Mar 4. 1907 to Catalan parents, she moved to Spain in 1915, became a nurse during the Spanish Civil War, and had three children. She recovered from COVID-19 at 113, was the oldest Spaniard ever, and was studied for her exceptional health, strong immunity, and youthful microbiome.
Maria Branyas lived through two world wars, the 1918 flu pandemic, the Spanish Civil War, and COVID-19. When she died in 2024 at age 117 years and 168 days, she was the oldest verified living person in the world. Now, scientists have examined her biology in unusual detail, and the results suggest that extreme aging and poor health are not always inseparable.
A team led by Dr. Manel Esteller, head of the Cancer Epigenetics Group at the Josep Carreras Leukemia Research Institute, has published the final peer-reviewed results from what researchers describe as the most comprehensive study ever performed on a supercentenarian. Using minimally invasive samples from blood, saliva, urine, and stool, the team analyzed Branyas’s genome, proteome, epigenome, metabolome, transcriptome, and microbiome.
The study, published in Cell Reports Medicine, was coordinated by Esteller and led by Eloy Santos. Its key finding is not that Branyas avoided aging. Instead, her biology showed two opposing patterns at once. As Esteller put it, she displayed a “fascinating duality: the simultaneous presence of signals of extreme aging and of healthy longevity.”
Clear Signs of Advanced Aging
The signs of advanced age were unmistakable. Branyas had very short telomeres (the protective caps at the ends of chromosomes), an immune system with pro-inflammatory features, an aged population of B lymphocytes, and clonal hematopoiesis, an age-related condition in which blood stem cells acquire mutations. These changes are often associated with higher risks of leukemia, myelodysplastic syndromes, cardiovascular disease, and other serious conditions. New research links social behavior shifts to health and work

Maria Branyas, the longest-lived person ever recorded, together with Dr Manel Esteller, from the Josep Carreras Leukaemia Research Institute Credit: Josep Carreras Leukaemia Research Institute
Yet Branyas did not develop cancer, dementia, or major cardiovascular disease. That contrast may be the study’s most important message: aging and disease can sometimes be separated at the molecular level.
Protective Biological Features
Alongside the markers of aging, Branyas exhibited several traits associated with resilience and healthy longevity.
The researchers found rare genetic variants linked to immune fitness, brain health, heart protection, and mitochondrial function. Her blood profile suggested unusually efficient lipid metabolism, with very low VLDL cholesterol and triglycerides and high HDL cholesterol, often called “good” cholesterol. She also had exceptionally low inflammation, a key factor because chronic inflammation is widely viewed as a driver of age-related disease.
Branyas’s gut microbiome also stood out.
Branyas had high levels of beneficial Bifidobacterium, bacteria associated with anti-inflammatory effects and healthy metabolism. This is notable because these bacteria usually decline with age, although they have also been found at higher levels in some centenarians and supercentenarians.
The researchers noted that Branyas ate about three yogurts per day during the last 20 years of her life, a habit that may have helped support her gut microbiome, although the study cannot prove cause and effect.
Younger Than Expected at the Molecular Level
Perhaps the most surprising result came from her epigenome, the chemical layer that helps regulate gene activity. Epigenetic clocks use DNA methylation patterns to estimate biological age, which can differ from chronological age. Across multiple tissues and several clock methods, Branyas’s biological age appeared younger than her actual age. One analysis found a gap of more than 23 years.
As the authors write, the findings suggest that one reason she reached such an extreme age was that her cells “felt” or “behaved” as younger cells.
Scientists Studied the World’s Oldest Person (117)… Here’s What They Found

Youthful traits identified in Maria Branyas. Credit: Santos-Pujol et al., Cell Reports, 2025
The researchers caution that one person’s biology cannot provide a universal formula for living past 110. Extreme longevity likely depends on a rare mix of genetics, lifestyle, environment, and chance.
Still, Branyas provides an unusually clear example of a body that carried the marks of extreme aging while avoiding many of aging’s most damaging consequences. The authors conclude: “These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy.”
Reference: “The multi omics blueprint of the individual with the most extreme lifespan” – Search Videos by Eloy Santos-Pujol, Aleix Noguera-Castells, Marta Casado-Pelaez, Carlos A. García-Prieto, Claudia Vasallo, Ignacio Campillo-Marcos, Carlos Quero-Dotor, Eva Crespo-García, Alberto Bueno-Costa, Fernando Setién, Gerardo Ferrer, Veronica Davalos, Elisabetta Mereu, Raquel Pluvinet, Carles Arribas, Carolina de la Torre, Francisco Villavicencio, Lauro Sumoy, Isabel Granada, Natalie S. Coles, Pamela Acha, Francesc Solé, Mar Mallo, Caterina Mata, Sara Peregrina, Toni Gabaldón, Marc Llirós, Meritxell Pujolassos, Robert Carreras-Torres, Aleix Lluansí, Librado Jesús García-Gil, Xavier Aldeguer, Sara Samino, Pol Torné, Josep Ribalta, Montse Guardiola, Núria Amigó, Oscar Yanes, Paula Martínez, Raúl Sánchez-Vázquez, Maria A. Blasco, Jose Oviedo, Bernardo Lemos, Julia Rius-Bonet, Marta Torrubiano, Marta Massip-Salcedo, Kamal A. Khidir, Thong Huy Cao, Paulene A. Quinn, Donald J.L. Jones, Salvador Macip, Eva Brigos-Barril, Mauricio Moldes, Fabio Barteri, Gerard Muntané, Hafid Laayouni, Arcadi Navarro and Manel Esteller, 24 September 2025, Cell Reports Medicine.
DOI: 10.1016/j.xcrm.2025.102368
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