Though sometime exhausted during long inpatient stays, she always found the energy to walk the hallways handing out seasonal treats such as candy canes and valentines.

Accompanied by her bunny, Mary played her way through some incredibly tough times. She emerged wearing a pink tutu and a smile.

“We like to say she danced her way out of the Hospital — she was wearing a tutu,       and she literally did,” her dad, Tom, says.

Headaches, MRI, then the diagnosis

The McKernans, of Philadelphia, were at the New Jersey shore in the summer of 2012 when Mary,  then 3,  began occasionally vomiting and complaining of headaches. The symptoms continued for about a week.  Her parents took her  to her pediatrician and  the local emergency room, but no one was sure what was wrong. Finally, on July 17,  her pediatrician sent Mary to CHOP for an MRI.

Before Mary woke up from sedation and rejoined her parents, they received a         phone call from her pediatrician, who told them that Mary had a brain tumor              and that someone from the CHOP surgical team would be with them soon.

Within minutes, neurosurgeon Phillip Storm, MD, arrived. He told them Mary          had a tumor in the cerebellum, the lower portion of the brain.

“My wife and I were in complete and utter shock after the phone call. Everything       was happening so fast, but Dr. Storm’s demeanor and confidence gave us some hope,” Tom recalls. “While we were devastated and in shock, we felt that we were in very, very capable hands.”

Experts in pediatric brain tumors

The Cancer Center at CHOP is home to one of the world’s largest, most skilled teams of oncologists and surgeons with expertise in pediatric brain tumors. They are leaders in patient care, and in research into the causes of pediatric brain tumors. Patients travel from around the world to be treated by this team.

Dr. Storm told the McKernans that based on the tumor’s location, he would likely be able to remove the entire tumor.

“We came out of the meeting feeling that this is a hopeful situation,” says Mary’s mom, Tricia. “His confidence gave us faith to just believe.”

Mary was admitted to the Pediatric Intensive Care Unit (PICU).

“Mary didn’t understand much,” Tom says. “She just knew  she had a headache and that being in the hospital would help her feel better. Everyone at CHOP was extremely compassionate and understanding. They spent a lot of time answering our questions because we were unable to remember half of the stuff we heard. We felt numb and that everything was a blur.”

Removing the tumor

During surgery three days later, Tom and Tricia were joined in the waiting room           by many friends and family members. A nurse came out with an update from the operating room every hour, reassuring them each time.

After seven hours, they were called into a consult room to meet with Dr. Storm. He   had been able to remove the entire tumor, but he suspected medulloblastoma, a rare cancer. Pathologists quickly confirmed this diagnosis. While the news that the tumor was malignant was very difficult, the McKernans were heartened by the fact that Mary’s cancer was not metastatic (had not spread).

Mary spent a week in the Hospital to recover, and then was able to spend some time at home.

She returned in August to begin chemotherapy. Mary’s treatment was overseen by  Jane Minturn, MD, PhD, one of nine neuro-oncologists on staff (neuro-oncologists have special expertise in brain cancers). Care for every child at CHOP with a brain tumor is a group effort, with surgeons and oncologists working together to devise       the best plan for chemotherapy and radiation based on the specific tumor type.

Chemo and stem-cell transplants

For the next nine months, Mary was in and out of the Hospital for chemotherapy and three stem-cell transplants.

“She would come up with all kinds of ideas of things to do,” Tricia recalls. “She would want to play hide and seek and go to the playroom. She would pretend she was the ice cream man or that her hospital bed was a boat in the middle of the ocean.

One of her occupational therapists even purchased a toy fishing pole and fish. She filled a basin with water and Mary would fish from the edge of her bed when she was too exhausted to move.”

Art and music therapists and child life specialists also helped keep Mary busy. Her parents hung her art on the walls of her room.

The team helped get her through the toughest parts. When Mary refused to take a particularly bad-tasting medicine, a nurse mixed it with grape juice and called it   “super power purple juice.” Mary drank it.

“The nursing teams are phenomenal here,” Tricia says. “Mary just loved every nurse she had.”

Proton therapy: new option for children

Mary’s treatment concluded with six weeks of proton therapy. Just a few years ago, radiation for brain tumors in children could cause irreparable damage. With proton therapy, a much more precise beam of radiation is applied, sparing surrounding brain tissue.

During Mary’s proton treatment, radiation was applied only to the tumor bed and         a tiny margin around it. CHOP is one of just a few institutions to provide pediatric proton therapy.

“We were so fortunate to have that option available so close to home,” Tom says.

Mary’s final proton therapy session was April 2, 2013. She was surrounded by family and friends as well as the nurses, doctors and staff who were on her radiation team when she rang the bell signifying the end of active treatment. Mary’s follow-up care      at CHOP will continue for years to come. Medulloblastoma requires very close monitoring, including regular brain MRI studies.

“We feel so fortunate to live in Philadelphia and to be so close to CHOP,” Tricia says.

Resuming play and ballet

When Mary first came home, her 2-year-old brother, Thomas, would run by her and grab toys right out of her hands. Her parents knew she was getting stronger when she began to refuse to relinquish the toys.

Nearly a year after became sick, Mary resumed ballet lessons. She will return to pre-school this fall. “For her to be able to play with her brother every day feels amazing,” Tricia says. “Every morning when we wake up at home now, for us is just amazing.”

Mary is a 4-year-old cancer patient at The Cancer Center at The Children’s Hospital     of Philadelphia (CHOP). She’s fighting brain cancer, and had surgery to remove her tumor. CHOP chose Mary to be a Childhood Cancer Awareness Month spokesperson and an ambassador for its largest annual fundraiser, the Four Seasons Parkway Run     & Walk, because she brightens the day of every person she meets.

In 2013, more than 10,000 children will be diagnosed with cancer, and about 1,500  will die from their disease. And although survival rates for many childhood cancers have improved dramatically over the past few decades, cancer is still the 2nd leading cause of death in children.

Clinical trials for childhood cancer are among the fastest and safest ways to find treatments that work against these diseases. Philanthropic support is critical to   funding ongoing research by our childhood cancer experts, and helping cover the   costs of enrolling children on experimental therapies.

Mary and her family and friends created a team for the 2013 Parkway Run & Walk,   and they’re asking for your support as they raise money for childhood cancer research and survivorship programs at The Children’s Hospital of Philadelphia. Run for Mary!   https://www.youtube.com/watch?v=DUzS1Wp6P2E