What is the first recorded use of cannabis?
Hermaphodites females can grow seeds under stressed conditions without pollen….aren’t void of the flowers and they are still useful, Hermies…. they are female but being able to pollinate themselves makes them She-males. But you will probably want to eliminate the seeds and seed pods before making medicine, they will make it taste even worse than it does regularly.https://www.youtube.
Cannabis: Myths and Realities
January 20, 2016
Learn what this growing market segment has to offer. Shoppers are increasingly interested in cannabis, and industry companies are developing more and more products to fill this need. But, not everyone (and every store) has accepted this burgeoning market with open arms. Confusion about the facts and realities may be the source of some of this hesitation. Here, several cannabis experts clarify some top myths about this herb and products sourced from it.
Myth: Hemp and Marijuana Are the Same Thing
While hemp and marijuana can both be derived from Cannabis sativa, marijuana can also come from other varieties of the same plant. Both products have unique and distinct compositions and usually come from different parts of the plant. Confused? You’re not alone.
Since both agricultural hemp and marijuana are Cannabis sativa, “many people interchangeably consider hemp as marijuana and vice versa. This is not true,” states Sarah Syed, director of marketing at CannaVest Corp., San Diego, CA. “The classification of the two related species make it hard for people to see that they are different.”
Jane Wilson, director of program development at the American Herbal Products Association (AHPA), Silver Spring, M.D., points out that there is actually a lot of diversity in the overarching title of “cannabis.” Hemp varieties of cannabis are low in tetrahydrocannabinol (THC) and can be used to make textiles, rope and building materials. “The oil from hemp seed is a nutritionally dense source of essential fatty acids and complete protein,” she states. The same cannot be said of marijuana.
And, Syed makes the point that the plants from which hemp and marijuana are derived have quite different characteristics, even though they are both Cannabis sativa. “Marijuana plants are short and bushy, and have high-THC in the flower,” she explains. “Agricultural hemp grows like bamboo, and has low levels of THC.”
To understand industrial hemp versus marijuana, it’s key to talk about some of the recent history about the sale of hemp-derived products. On October 9, 2001, the Drug Enforcement Administration (DEA) published an Interpretive Rule about the sale of hemp in the Federal Register banning the sale of any hemp products with trace amounts of THC in them. Patent No. 6,630,507: Why the U.S. government holds a patent on cannabis plant compounds
The Hemp Industries Association and others filed an “Urgent Motion of Stay” and after much back and forth, a key decision was made by the Ninth Circuit in the case of Hemp Industries Assn., vs. Drug Enforcement Admin., 357 F.3d 1012 (9th Cir. 2004), which recognized that “non-psychoactive hemp [that] is derived from the ‘mature stalks’ or is ‘oil and cake made from the seeds’ of the Cannabis plant,…fits within the plainly stated exception to the [Controlled Substance Act] definition of marijuana.”
In other words, the DEA cannot completely ban hemp products with THC, if they are derived from the stalk and stem of hemp grown outside the United States.Will Kleidon, CEO and founder of Ojai Energetics LLC, Ojai, CA, adds that there may be some changes to these rules in the future, however. “Some people are saying that the 2014 Farm Bill redefines hemp as the whole plant,” he states, adding that using the flowers and parts of the plant outside the stalk and stem may only be legal for research purposes and not for interstate commerce yet. https://topdocumentaryfilms.com/cannabis-research-studies/
Preview CANNABINOIDS AT WORK, CANCER/
The cannabis plant has more than 80 cannabinoid constituents. In fact, most of them cause no psychotropic effects at all. Says Nicole Smith, founder and CEO, Mary’s Medicinals & Mary’s Nutritionals, Denver, CO, “A common misconception is that all cannabis ‘gets you high.’… Most of the therapeutically beneficial compounds that we can extract from cannabis will not cause any psychotropic effects…It is important that retailers understand that there is a lot more to the cannabis plant than just THC.”
One specific cannabinoid, THC, is vital to understanding the cannabis market, however. Wilson explains this compound is responsible for marijuana’s psychoactive effects. “Retailers in states with medical cannabis laws and/or adult use laws can provide or sell products containing THC, but it remains a substance prohibited under federal law by the Controlled Substances Act,” Wilson states. “Retailers electing to sell products containing THC must have an excellent understanding of the licensing and compliance requirements in their state, as well as to whom they can legally sell or provide products under state law.”
THC content is restricted in legal products like CBD oil. Robert LoMacchio, president of Only Natural, Inc., Island Park, NY, believes that THC is not well understood at all, with some believing CBD oil has psychoactive or intoxicating effects. “The truth is, it is believed to have an anti-psychotic effect and could actually be used for anxiety and stress support. In some individuals, it may have a calming effect on the mind and body,” he states.
According to Kleidon, “The psychoactive threshold is set at 0.3% THC, based on the Farm Bill and interstate standards for hemp.”
Conventional hemp-based CBD oils, LoMacchio adds, are standardized to contain less than that legal limit.
To put this trace amount into perspective, Richard Rose, executive director of the Medicinal Hemp Association, states that marijuana’s THC content can be as high as 25%.
Kleidon notes that 0.3% THC may be a fairly conservative percentage threshold, as some research shows psychoactive thresholds at 1% THC or even higher. Nonetheless, his firm actually uses a far lower threshold in its products: 0.03%. He says his company has a patented technique for turning the fat-soluble ingredient into a water-soluble one, thereby improving absorption rate and bioavailability (estimated at 10x). Therefore, less THC is required.
Kleidon believes that having some THC in hemp-derived CBD oils is key for a product’s bioavailability and efficacy. He is suspicious of CBD oils that are void of any cannabinoids with the belief that it may not be efficacious.
Another interesting point comes from Rose, who says THC is actually not psychoactive in its raw form. “It is not psychoactive until heated (“decarboxylated”) and converted to psychoactive THC,” he states, noting that raw marijuana is about as psychoactive as potatoes or corn. “Same with cannabis. Eat and also juice it freely for whole plant acid cannabinoids without the high,” he states.
Myth: Regulators Have Outlawed the Sale of CBD Oils as Supplements
According to Rose, “There has never been one raid or arrest for selling CBD in any store, and the U.S. Food and Drug Administration (FDA) has never said it was illegal or couldn’t be sold.”
But that doesn’t mean FDA has been completely silent about CBD oils sold as dietary supplements. In February 2015, FDA sent several warning letters to several companies telling them that the CBD oils were making unsubstantiated disease claims or they did not contain any CBD at all (according to testing conducted by the agency).
Wilson says it is not unusual for companies selling supplements that are out of compliance to receive warning letters, and no, “The warning letters did not otherwise address the legality of CBD supplement products.”
Syed says that many CBD companies are new to the dietary supplements industry and are unfamiliar with DSHEA and the legal parameters of selling supplements.
She states, “Many CBD companies have been touting health benefits that legally we aren’t able to say based on laws established by the FDA, even if they may be true.”
Syed says her company’s strategy is to focus on education. “We have to help guide the standards of this new category. We are doing what we can to help make sure we can all remain in this space together, touting benefits we know that are appropriate and legal to say.”
What may have caused some industry members to believe FDA doesn’t like the idea of CBD oils being sold as supplements is its Question and Answer webpage on medical marijuana. Here, says Wilson, “[FDA] stated its position that CBD is not a dietary ingredient because of the filing of Investigational New Drug (IND) applications and ongoing clinical trials for its use as a registered pharmaceutical. AHPA is not aware of any enforcement action taken by FDA against marketers of CBD supplement products since that position was made public.”
WholeFoods has spoken to some companies that feel this opinion is clear enough to make them reposition CBD-containing dietary supplements to food products instead. LoMacchio’s interpretation of FDA’s viewpoint, for instance, is “Hemp-based CBD oils must be marketed as a nutritional foods or food additives, not as dietary supplements.” He is hopeful that with additional research, regulators will show full support of the use of CBD oils as dietary supplements.
Smith’s company also chooses to market its products outside the supplements realm. “While industry lawyers have indicated that the referenced letters and Q&A posting are far from a final determination on this issue, we are not offering any CBD supplements or medicines. We never make any claims about these products,” she states, noting that her firm’s products are classified as cosmetics or food products that are rich in high-quality CBD.
It is also possible that FDA’s opinion has made some companies shift from a CBD focus to “hemp oil” or “hemp extract.” Wilson suggests that some CBD oil companies may also have chosen to sell their products in states that have legalized marijuana for medical and adult-use purposes or through licensed dispensaries in these states.
Still others, like Ojai Energetics, believe the sale of CBD oil as a supplement falls within the regulatory framework, provided it is made following FDA’s GMPs for dietary supplements, appropriate analytical testing is conducted and no unsubstantiated disease claims are being made. Ojai Energetics sells CBD oils as supplements and as foods in places like natural products stores and licensed dispensaries.
Rose believes one could make that case that CBD is grandfathered in as a legal dietary ingredient “just like hempseed oil and whole hempseed as a food, and ironically even more-so than shelled hempseed, which was introduced after DSHEA. But just like hempseed and oil, or echinacea and gingko for that matter, companies make health claims at their peril.”
There is another angle to the warning letters and Q&A page. Says Rose, “It appears FDA agrees with what those of us have known for years: Cannabidiol in hemp is not a Controlled Substance. Period. Otherwise, FDA would be talking RICO organization with multiple underlying felonies against the officers of the business.”
Reality: CBD Oil May Throw Drug Testing
According to Kleidon, it is possible that certain individuals who use large amounts of THC-containing products may test positive on urine drug tests. He states, “People who get drug tested and use large amounts of THC products should be careful and use at their own discretion.”
Myth: Cannabis Products Are Only for Pain Relief
For starters, retailers cannot promote cannabis-derived products like CBD oil as pain relievers. This is a disease claim, and not an appropriate way to frame how cannabis products benefit the body.
But without question, supporters are convinced that hemp-derived products bolster optimal health in numerous ways. Kleidon attributes these effects to the human endocannabinoid (EC) system, which was discovered in 1988. “We now believe its function is to regulate homeostasis for the entire body,” he states.
Syed adds that CBD “is capable of affecting nearly every biological process.”
How does THC affect behavior? It depends on where the CB receptors are in the brain.
Brain Structure Regulates THC Effect on User
Amygdala emotions, fear, anxiety panic/paranoia
Basal Ganglia planning/starting a movement slowed reaction time
Brain Stem information between brain and spinal column anti nausea effects
Cerebellum motor coordination, balance impaired coordination
Hippocampus learning new information impaired memory
Hypothalamus eating, sexual behavior increased appetite
Neocortex complex thinking, feeling, and movement altered thinking, judgment, and sensation
Nucleus Accumbens motivation and reward euphoria (feeling good)
Spinal Cord
transmission of information between body and brain altered pain sensitivity
For more facts about marijuana and other drugs, visit; teens.drugabuse.gov or scholastic.com/headsup.
The EC system is a communications system in the brain and body, and it affects many bodily functions such as emotions, movement and more (1). The body naturally produces chemical messengers called cannabinoids to interact with the EC system in a unique fashion. Says Rose, “That means everyone is born to produce ECs naturally, so adding external cannabinoids is just adding more of what we already have in us. Mother’s milk, for instance, is very high in ECs naturally.”
When a postsynaptic neuron is activated, the body makes cannabinoids from certain fat cells present in neurons. When they are released, they travel backward to the presynaptic neuron and attach to cannabinoid receptors. This means cannabinoids can control what happens the next time these cells are activated, limiting how much neurotransmitter is released and how cells send, receive and process messages (1).
Syed believes that CBD can support numerous bodily processes for this reason. “Phytocannabinoids like CBD, of which well over 100 have been found to exist, are plant derivatives that ‘talk’ to just about every major organ system in the body via the ECS, helping restore normal balance and physiologic homeostasis.”
According to Kleidon, cannabinoid receptors are present in the brain, organs, skin, bones, fascia, immune system and digestive system. “Their function is to support homeostasis for the entire body, which in my opinion, is one of the most important systems we have. It’s a master system for all the other systems,” he says.
Supplementing with CBD, he believes, boosts the body’s natural cannabinoid levels. “In my opinion, it’s absolutely vital to supplement and raise natural cannabinoid levels to make sure it’s promoting our bodies’ homeostasis effectively,” Kleidon states.
Smith shares a similar belief that cannabis products should be widely used, and says it is a misconception that cannabis is only used by “a certain type of people.” She states, “Everyone from soccer moms to professional athletes and especially seniors are beginning to explore the benefits of cannabis for varied reasons. We sponsor an ultra-runner who uses our products while training for 100–200 mile marathons—so much for the stereotype of the lazy, out-of-shape stoner!”
Researchers continue to explore the benefits of CBD oil, which may include bone, digestive, eye, respiratory and cognitive health as well as healthy mood. Experiments also suggest, Rose says, that CBD even induces apoptosis in cancer cells and generates new brain cells, though more research is needed before it can be considered to be a treatment. “Every adult human and animal can benefit from cannabinoids,” he believes.
Meanwhile, hemp seed, hemp seed oil and hemp-derived foods are already readily available at many retail stores, and provide “nutrient dense options for consumers interested in trying them,” says Wilson.
Reality: Product Testing Is Critical to this Category
All dietary supplements must be made according to GMPs and undergo responsible analytical testing. Hemp products are no exception.
Kleidon explains that the cannabis plant is a dynamic accumulator, meaning it pulls up heavy metals. If the plant is grown in toxic soil, the plant “cleans the soil” and absorbs the impurities. “That’s not good for a consumption-based product,” he states.
Smith says that for this reason, organic crops from trustworthy suppliers are preferable since there is little chance of pesticides or environmental toxins contaminating the plants.
Kleidon says that it is very important for companies to do third-party testing per batch for heavy metals, microbes, volatile organic compounds as well as for the right cannabinoid and terpene content. “People should know exactly what they’re getting every single time,” he states. The best strains of cannabis?
Aiming High: Israeli Scientist Attempts To Kill Cancer Cells With Cannabis
These days, cannabis is about a lot more than getting high; a new Israeli study supports the idea that cannabis could be used to kill cancer cells.
Biologist Dr. David Meiri of the Technion-Israel Institute of Technology is conducting cutting-edge research showing that combinations of different compounds in cannabis can be extremely effective in destroying specific cancer cells.
SEE ALSO: Turning High-Tech Into ‘High’ Tech: Behind Israel’s Blooming Medical Cannabis Industry
According to the World Health Organization, cancer is the second leading cause of death globally, and resulted in 8.8 million deaths in 2015. The primary medical treatment, chemotherapy, can have unpleasant side effects such as hair loss and lethargy. However, an Israeli researcher claims that cannabis could offer an alternative to chemotherapy, without the harmful side effects.
The idea that cannabis could cure cancer is not new. However, much of the evidence is anecdotal, and scientific research conducted in the past has not precisely identified which cannabis compounds kill which cancer cells, and why. “We realized that there is a vacuum,” Meiri tells NoCamels. “People don’t know and understand the strains [of cannabis] enough.”
Along with his team of 30 researchers in the Laboratory of Cancer Biology and Cannabinoid Research, Meiri is working to remedy this. His solution is to identify the exact chemical composition of different strains of cannabis. By systematically applying these strains to different cancer cell samples, he has been able to determine which strains of cannabis kill specific cancer cells.
“Bringing back the ability of the cancer to commit suicide”
The mechanism is similar to chemotherapy. One of the defining characteristics of cancer cells is their inability to ‘die’ like normal cells. The natural process of self-destruction, termed apoptosis, is not occurring; as a result, the cancer cells spread and invade other parts of the body. What cannabis has the potential to do, according to Meiri, is “like bringing back the ability of the cancer to commit suicide.”
Meiri is optimistic about the potency of the drug. “We’re talking about very low dosages,” he tells NoCamels, “milligrams of extract that are killing the cells.” This is a similar dosage to what is currently administered for chemotherapy, and is small enough to not kill normal, healthy cells. It means that cannabis could be a viable drug to be prescribed for cancer in the future.
SEE ALSO: Cannabis Heals Bone Fractures, Makes New Bones Even Stronger
Cannabis is the name of the plant from which marijuana is derived. The plant itself is made up of different molecular families, such as cannabinoids, terpenes, and flavonoids. Discussions on cannabis often focus on the two most prominent cannabinoids: THC and Cannabidiol (CBD). THC is a psychoactive compound that gives the ‘high’ commonly associated with marijuana usage, while CBD is non-psychoactive. Both have been proven to have a wide range of medicinal benefits, from reducing epileptic seizures, to minimizing violence and anxiety in autistic patients.
Raphael Mechoulam is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel. He is best known for his work (together with Y. Gaoni) in the isolation, structure elucidation and total synthesis of Δ9-tetrahydrocannabinol, the main active principle of cannabis and for the isolation and the identification of the endogenous cannabinoids anandamide from the brain and 2-arachidonoyl glycerol (2-AG) from peripheral organs together with his students, postdocs and collaborators.
Recent progress in several areas will be discussed:
- Endocannabinoids as endogenous neuroprotective agents, particularly in traumatic injury
- The CB2 cannabinoid receptors as part of a general protective system
- Acyl fatty acids as novel endocannabinoid-like compounds
- Cannabidiol as a novel therapeutic entity
Presentation https://www.youtube.com/watch?
Dr. David (Dedi) Meiri
Assistant Professor, Heads the “Laboratory of Cancer Biology and Cannabinoid Research”, Technion, Israel Institute of Technology.
Ph.D, Assistant Professor Genetics, Cell Biology, Molecular Biology researcher
Dr. Meiri’s scientific background is highly diverse; He holds a M.Sc. in Biochemistry and a Ph.D. in plant biotechnology from Tel Aviv University. Dr. Meiri conducted his post-doctoral fellowship at the Ontario Cancer Institute where he focused on the role of the GEF-H1 protein in tumor invasion and metastasis.
During his post-doctoral studies, he expanded his knowledge in human biology and cancer pathogenesis and succeeded within a very short timeframe, to receive worldwide recognition as an expert in the fields of G-protein coupled receptors (GPCRs) and small GTPases. Upon completion of his post-doctoral fellowship, Dr Meiri took a position at the Technion Israel Institute of Technology, where he heads the “Laboratory of Cancer Biology and Cannabinoid Research”.
Presently, his lab is investigates the therapeutic potential of phytocannabinoids, the unique active compounds of Cannabis. On-top on few other studies conducting in the lab, the main focus is to determine the antitumor effects of cannabinoids, including the anti-metastatic and pro-apoptotic effects phytocannabinoids exert, on a spectrum of tumor cells.
Welcome to the Laboratory of Cancer Biology and Cannabinoid Research at the Technion‘s Faculty of Biology. Although we are a new lab, in the past 2 years we have updated our lab to work with the most modern and innovative equipment, we recruited a multidisciplinary team of professionals, we have established many local and international collaborations.
Collectively with access to these resources, we can ask and answer almost any question in the field of medical cannabis and we are today one of the leading cannabis laboratories in the world. Our highly trained team of skilled professionals work in synergy and complement each other to achieve the highest level of results.
Presently our lab investigates the vast therapeutic potential of naturally-occurring chemicals, called cannabinoids, in various Cannabis species. In addition to the multitude of other studies currently being conducted in the lab, our principal focus is how cannabinoids affect various types of cancer, epilepsy, and glucose metabolism (diabetes).
Our research also relies upon our exceptional abilities to characterize all cannabis components and are described in more details on this site. Our lab is also involved in various other high-profile projects and collaborations associated with cannabis. We collaborate with cannabis growers, clinicians, and major local and international medical cannabis manufacturers and distributors to revolutionize cannabis treatment on all levels. We are operating the “Cannabis Database Project” and we are currently involved in eight clinical trials covering diverse aspects of cannabis treatment.
The Laboratory of Cancer Biology and Cannabinoid Research
Phone: +972-77-8871681
Email: meirilab@technion.ac.il
Faculty of Biology, Room 401
Technion-Israel Institute of Technology
RSO Oils Does Not Kill All Cancers! Please Do Not Waste Your Time & Money on Medical Cannabis if you have NSCLC Cancer. Over the last 3 years I have used High THC RSO Oils in Mega Doses (3 mils RSO Consitrated Oil per day) for 90 days, Micro Dosing and Height & Weight Measured Dosing 1/2 Mil of RSO Oil over 3 doses per day for 90 days.
I’ve seen Professional MC Practionairs in San Francisco, Marin County & Australia and the TRUTH BE TOLD by one of the most experienced Practionairs is most of their successes have been with tumours that are outside of a bodily organ. Tumours inside organs, like the Lungs the successes have been very few (if any) and they felt better results came when tried with some conventional western medicine (Radiation, Chemo & Immunotherapy.)
I personally, would not do Chemo (Immune System Poison), but do whatever you need to do. I’m just being truthful with you so you don’t waste your money & time trying RSO Oil by itself on NSCLC Cancer. If your lung collapses like mine did, the doctors will tell you it will never reopen again after a few months closed. DO NOT BUY THAT CRAP. Take High Doses of Vitamin C daily at least 15,000 IU orally “California Gold” find it on Iherb.au, it’s only about AU$30 for 360 caplets of 1000 IU per. (In the store here in Australia the same bottle cost AU$75 – $80) I take 8 in the morning and 7 at night to get my 15,000 per day. That will help keep the lung healthy enough to reopen when that portion of your lung gets air. Mine reopened 10 months later after 3 – 4 doctors swore to me there was NO CHANCE that lung would reopen. It did and it still is.
I have NSCLC Cancer and I’m now at Stage 4 where the Cancer has spread to my Lymph Nodes and few other spots on my lungs. I was originally diognosed back in March 2015 from a CT Scan after vomiting Blood and since then I have narrowly escaped death twice (Once Drowning in My Own Blood, Couching it Up, While Bleeding from the Nose at the sametime & Once where I was Bleeding Out After Losing over a Litre of Blood in 8 hours Vomiting Blood and Bleeding out of my Nose)
What is the Best Way for Patients to Consume Cannabis? – https://www.google.com/search? source=hp&ei=HxGrWvPtEYijzwL_o 7_AAg&q=Is+there+a+type+of+THC +%E2%80%9Ctar%E2%80%9D+or+past e+that+helps+with+pain+and+can cer+available%3F&oq=Is+there+a +type+of+THC+%E2%80%9Ctar%E2%8 0%9D+or+paste+that+helps+with+ pain+and+cancer+available%3F&g s_l=psy-ab.12…1737.1737.0.28 97.3.2.0.0.0.0.90.90.1.2.0…. 0…1..64.psy-ab..1.1.129.6..3 5i39k1.129.Xciws9qmyi8
Preview Israel Has The World’s Largest Medical Marijuana Program