How The Body Works

The Human Genome Project: aimed to map the entire human genome; this map is effectively a blue print for making a human. Using this information researchers have been able to identify the genes that contribute to various diseases. By logging common variations in the human population, researchers have also actually been able to identify 1,800 disease associated genes. https://www.youtube.com/watch?v=nvUuqt94lEE

If mutations are introduced in the sperm and egg cells they can be passed on to the next generation. However, not al…l mutations are bad. This process of randomly introduced changes in the DNA sequences provides the biological under pinning that supports Darwin’s Theory of Evolution.

This is most easily observed in animals, take for example the peppered moth. Before the industrial revolution the majority of these moths had white wings enabling then to hide against the light-coloured trees and lichens. A minority had a mutant gene which gave them black wings, making them easy prey for predators.

When factories began covering trees in soot, the light coloured moths moths struggles to hide themselves to protect themselves. So black moth flourished, enabling them to pass on their mutation to their off springs altering the gene pool. Therefore it is easy to see how a genetic change can give a moth an advantage can also produce genetic disease? https://www.youtube.com/watch?v=LyRA807djLc

Cancer usually begins with one tumor in a specific area of the body. But if the tumor is not removed, cancer has the ability to spread to nearby organs as well as places far away from the origin, like the brain. How does cancer move to these new areas and why are some organs more likely to get infected than others? Ivan Seah Yu Jun explains the three common routes of metastasis.

Lesson by Ivan Seah Yu Jun, animation by Andrew Foerster. https://www.youtube.com/watch?v=OcigJn8UJNQ

However when it comes to cancer DNA is only part of that story:

According to the January 20, 2010 issue of Journal of the American Medical Association, 68 percent of adults are in the United States are over weight or obese. America loves enemies, at some point when we noticed we were getting fat; we made fat the enemy and attacked it. Everything became fat free and we replaced it with carbohydrates and as a result e became the fattest country in the world.

Therefore, we became a fat free country searching for fat free foods loaded with sugar. Once a person ingest this sugar the pancreas secretes insulin — a fat producing hormone — to lower the rise in the body’s sugar levels. So as this excess energy comes along and the body has to store it some where. In the short term it is stored in the liver.

However with this living in excess energy, the body produces more fat cells thinking it can burn it later. Trouble is with a diet trap of this sort, there’s really never is a later. When your on a fat free or low fat diet you’re constantly craving. Why? because your body needs the correct ratios of good fat and protein to function properly.

If you cut out either of those your body will cry out for them. We’ve have been trapped into believing a fat free or sugar free diet is healthy and it’s not. A lot of these products contain toxic ingredients that are incredibly bad for you. Many of these ingredients promote dis~ease within your body Omega 3s (anti inflammatory) omega 6s pro inflammatory.

Healthy fats are usually found in food in natural plant and animal based foods. Such as avocados, chia seeds, hemp seeds, flax seeds or wild caught salmon or trout. The good news people are wising up to the marketing of fat free. Are eliminating soda pop that contain phosphoric acid which cause lost bone mineral density and chemical sweeteners that cause neurological problems and Sodium Benzoate (E211) is a preservative used to prevent food from molding.

OMEGA 3 – Eskimo women who have a high concentration of omega 3 fatty acids in their diet have a lower incidence of breast cancer. Omega 3 fatty acids – found in fish – block the effect of estrogen on breast cells, thus lowering the risk of them becoming cancerous. http://www.chimachine4u.com/cancer-diet.html

Due to the opposing effects of omega-3 and omega-6 fatty acids, a healthy diet should contain a balanced omega-6:omega-3 ratio. Human beings evolved eating a diet with a omega-6:omega-3 ratio of about 1:1. Modern Western diets exhibit omega-6:omega-3 ratios ranging between 15:1 to 17:1. Epidemiology and dietary intervention studies have concluded that while an exceptionally high omega-6:omega-3 ratio promotes the development of many chronic diseases, a reduced omega-6:omega-3 ratio can prevent or reverse these diseases.

For example, a ratio of 4:1 was associated with a 70% reduction in mortality in secondary coronary heart disease prevention and a ratio of 2.5:1 reduced rectal cell proliferation in patients with colorectal cancer. A lower omega-6:omega-3 ratio in women was associated with decreased risk for breast cancer. A ratio of 2:1–3:1 suppressed inflammation in patients with rheumatoid arthritis, and a ratio of 5:1 had a beneficial effect on patients with asthma, whereas a ratio of 10:1 had adverse consequences.

Furthermore, a high omega-6:omega-3 ratio is especially detrimental to carriers of certain genetic variations. For example, minor allele carriers of the APOA5 gene have elevated triglycerides levels and minor allele carriers of 5-lipoxygenase polymorphism in the gene promoter region exhibit increased risk for atherosclerosis. Other gene polymorphisms that are affected by this ratio include CD36 (a cell surface scavenger receptor) and TCF7L2 (a transcription factor). Lowering the omega-6:omega-3 ratio is particularly important for these variant carriers to prevent chronic diseases.

It is clear that many plant seed oils contain no omega-3. Long-term ingestion of these oils without supplementing omega-3 from other sources will gradually incur hyperimmune responses and associated chronic diseases. It is also clear that most animal-based fats are actually well-balanced with regard to the omega-6:omega-3 ratio (chicken fat is an exception), but due to the high percentage of saturated fat, consumption of animal fat still needs to be restricted in an appropriate amount.

Overall, canola oil has the most balanced fatty acid composition, not only due to a good omega-6:omega-3 ratio, but also because it contains a high percentage of monounsaturated fat which is beneficial to human health. Olive oil, although moderately high in the omega-6:omega-3 ratio, also contains a high percentage of monounsaturated fat. Most importantly, olive oil also contains a high amount of antioxidants and the substance squalene that has been shown to have anti-cancer effects. Therefore, olive oil is another good choice of healthy food oil. Deep sea fish oils such as salmon fat are excellent sources of omega-3. Flaxseeds oil is also a rich source of omega-3. It is a good option to use for a omega-3 supplement.

When you’re recovering from heart disease, stroke or want to prevent cancer (this is important.)

The thing is… Omega-6s and Omega-3s don’t have the same effects. Omega-6s are pro-inflammatory, while Omega-3s have an anti-inflammatory effect (1).

Of course, inflammation is essential for our survival. It helps protect our bodies from infection and injury, but it can also cause severe damage and contribute to disease when the inflammatory response is inappropriate or excessive.

…

In fact, excess inflammation may be one of the leading drivers of the most serious diseases we are dealing with today, including heart disease, metabolic syndrome, diabetes, arthritis, Alzheimer’s, many types of cancer, etc.

Put simply, a diet that is high in Omega-6 but low in Omega-3 increases inflammation, while a diet that includes balanced amounts of each reduces inflammation https://authoritynutrition.com/optimize-omega-6-omega-3-ratio/

“Around 11 million people are diagnosed with cancer each year around the world. The most common forms of cancer include colon and rectal cancer, lung cancer and – depending on sex – breast or prostate cancer. By 2030 the number of cancer patients is expected to double because of demographic changes (1). After a period of stagnation, conventional medicine has once again achieved substantial improvements in treatment outcomes in recent years, and for some tumor entities has even achieved longer survival rates.

These successes are due in part to new principles of medicinal treatment, and in part to improved diagnostic methods and radiation technology. At the same time, therapies have become more intense and in some cases more aggressive, and in consequence their side effects are often worse (2). Simultaneously, the desire of oncology patients for gentler therapeutic procedures and complementary treatments has greatly increased over the past 15 years.

Today, many cancer patients take vitamins and other micronutrients to augment their standard treatment or to reduce the side effects associated with the illness or its treatment (3). Among oncologists there are justified concerns that dietary supplements could impair the effectiveness of chemo- or radiotherapies (4). The use of micronutrients as complementary medical treatment must therefore always be designed and timed to avoid diminishing the effectiveness of oncological therapies.

The success of treatment and the healing processes in cancer patients are greatly influenced by nutritional status. This is of major clinical relevance, because depending on the type of tumor, its location and the stage of the disease, 30% to 90% of patients will be malnourished. The most severe form of tumor-associated dietary deficiency is cancer cachexia, a wasting condition with loss of weight, appetite and muscle mass. It is especially common among patients with bronchial, gastric, pancreatic or prostate carcinomas. Nutritional deficiencies weaken the immune status, reduce tolerance to treatment and interfere with several organic and metabolicMetabolism.

Preview The Human Gut Microbiome – Its Impact on Our Lives and Our Health

rain gutter, a healthy lymph system drains excess fluid from your body’s tissue so that it doesPreview YouTube video Our Microbiome – Health Matters

Our Microbiome – Health Matters

n’t pool. However, if there’s to much fluid it can spill over. Trust me, you don’t want a sggish lymph system. Because it can lead to water rion, most often in the arms or legs. Unlike with blood, which is propelled by your heart there’s no pump to help drive lymph.
Instead, it gets around through subtle squeezing of muscles that happens when you move. So aim to get 30 minutes of exercise daily to encourage normal lymph flow. Also consider yoga, because the deep, diaphragm – engaging breathing may stimulate your lymphatic system. Your lymphatic and circulatory system works in unison and are mapped out next to each other.

Each time your blood completes a lap of the body, it leaves behind 1% of its fluid content in the tissues. This is absorbed by nearby lymph capillaries to become a clear substance called lymph. Lymph travels through lymphatic vessels one -way highway that run from your outer peripheries to the heart.

The mission of this internal road trip is to return the missing fluid to the circulatory system while protecting you from illness. Immune cells in lymph keep invaders (bacteria and viruses) out. Lymph nodes are located in clusters, from behind your ears all the way down to your knees.

While alarming, a swollen lymph node is a good sign. It means your immune system is working to fight an infection in a nearby part of your body. So what’s going on? When your body identifies a threat, the number of immune cells in the node dramatically increases to prep for a fight causing the node to balloon. This is the reason exercise is important when you have cancer!!!!

Preview YouTube video The Lymphatic System, Part 1

The Lymphatic System, Part 1

uman Gut Microbiome – Its Impact on Our Lives and Our Health

A set of physical and chemical reactions that occur in living organisms in order to maintain life, such as digesting food and nutrients, eliminating waste through urine and feces, circulating blood, and breathing. The chemical reactions can be catabolic (catabolism) ─ breaking down organic molecules (e.g., nutrients) to generate energy ─ or anabolic (anabolism) ─ using energy to construct components of cells such as proteins and nucleic acids. functions.

The response to and effectiveness of tumor destruction treatments (chemotherapy, radiotherapy) may be diminished, while the rate of side effects and the risk of therapy-associated complications rise. In consequence patients face a poorer quality of life and prognosis (5). Malnourished cancer patients have increased morbidity and higher mortality rates; fatalities are around 30% higher in cancer patients with malnutrition. Malnutrition does not only relate to energy-providing macronutrients (carbohydrates, proteins, lipidsLipids (in the blood)

Lipids are fatty substances found in the blood that can be used by the body to transport some vitamins and are an energy source. The blood lipids include cholesterol and triglycerides. Some lipids enter the body through what we eat. Some are created within the body itself. ), but also involves the biocatalytic and immunomodulatory micronutrients. Since macronutrients are the natural carriers for micronutrients, malnutrition is one of the main causes of inadequate micronutrient status in cancer patients. Moreover, inflammatory processes as well as the side effects of chemo- or radiotherapy (e.g. vomiting, diarrhea, loss of taste) can increase micronutrient requirements and utilization.

Cancer patients generally have a poorer nutritional status than healthy people – indeed their provision with several vitamins and trace elements is often insufficient at the time of diagnosis and before the appearance of clinically relevant changes to the nutritional status. It deteriorates even more after starting cancer therapy.

However, the availability of micronutrients with antioxidantAntioxidant
Antioxidant substances, such as vitamins and carotenoids, are thought to protect the body against the destructive effects of free radicals. Antioxidants neutralize free radicals by donating one of their own electrons, ending the electron-“stealing” reaction. They act as scavengers, helping to prevent cell and tissue damage that could lead to cardiovascular disease and cancer.

Oxidation of low-density lipoprotein (LDL) cholesterol is important in the development of fatty build-ups in the arteries (see Atherosclerosis). Antioxidant substances, such as vitamins and carotenoids, can potentially prevent LDL oxidation and its harmful effects. and immunomodulatory activity (e. g. vitamin C, vitamin E, beta-carotene, selenium and vitamin D) and those with a low storage or reserve capacity (e. g. B vitamins and vitamin K).

Since a micronutrient deficit in cancer patients due to a tumor or therapy exacerbates the course of the disease and detracts from the efficiency of tumor destruction treatments, as well as increasing the risk of associated complications (e. g. diminished immunocompetence, poor wound healing, exhaustion, depression), care should be taken to ensure an adequate intakeAdequate Intake (AI)

Defines a daily dietary intake level for a nutrient sufficient to meet the requirements. However, the amount established is somewhat less firmly believed to be adequate for everyone in the demographic group than the Recommended Daily Allowance (RDA). An AI is set when no RDA has been established. of energy substrates (proteins, lipids, carbohydrates) and also an optimum intake of immune stabilizing micronutrients like selenium and vitamin D.

The importance of antioxidant micronutrients as an adjunct to nutritional therapy is substantiated by results from several studies which have shown that consuming multivitamin and mineral preparations can enhance both the quality of life and the prognosis for cancer patients (6, 7). Antioxidant micronutrients like vitamin C, vitamin E, vitamin A derivatives and selenium not only act as radical scavengers, but also perform a number of other essential metabolic tasks apart from their antioxidant cell-protective functions. Foremost among these are their immunomodulatory, apoptosis (cell death) inducing and cell division and differentiation regulating properties (1).

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A GREEN JUICE RECIPE TO HEAL EVERY DISEASE!

Supplementation with antioxidants during tumor destruction treatments is still the subject of controversy, since the ability of radiotherapy and of some cytostatic agents to destroy tumors is based in part on the formation of free radicalsFree radicals
Free radicals are unstable molecules (e.g., oxygen) with an unpaired electron. They are very reactive, (e.g., reactive oxygen species) trying to capture the needed electron to gain stability. Generally, free radicals attack the nearest stable molecule, “stealing” its electron. When the attacked molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started it can cascade, finally resulting in the disruption of a living cell. Some free radicals arise normally during metabolism.

Sometimes the body’s immune system’s cells create them to neutralize viruses and bacteria. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also generate free radicals. . However, the effect of most of the cytostatic agents currently used in cancer treatment, such as antimetabolites (e.g. methotrexate), nitrogen mustard derivatives (e. g. cyclophosphamide), platinum complexes (e. g. cisplatin), vinca alkaloids (e. g. vinorelbine), taxanes (e. g. paclitaxel) or anthracyclines (e. g. epirubicin) is not primarily brought about by oxidative stressOxidative stress’

A condition, in which the effects of oxidizing substances (e.g. free radicals, reactive oxygen and reactive nitrogen species) exceed the ability of antioxidant systems to neutralize them. . If antioxidants did have a significant influence on the ability of standard therapies to destroy tumors, consumption of fruit and vegetables rich in antioxidants and phytamin or green tea (which is rich in epigallocatechin) would not be allowed during the treatment phase. There is consequently no justification for the frequently sweeping and uncritical rejection of supplementation with antioxidant and immunomodulatory micronutrients during the chemotherapy phase of treatment’

Systematic reviewsSystematic Review
(also known as a systematic overview)

A review of a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise relevant research, and to collect and analyze data from the studies that are included in the review. of randomized controlled studiesRandomized Controlled Trial (RCT).

A clinical trial with at least one active treatment group (e.g., taking a vitamin) and a control (e.g., placebo) group. In RCTs, participants are chosen for the experimental and control groups (e.g., placebo-controlled) at random, and are not told whether they are receiving the active or placebo treatment until the end of the study. A RCT in which neither the investigators administering the treatment nor the participants know which participants are receiving the experimental treatment and which are receiving the placebo is called “double blind”. RCTs are always prospective studies.

RCTs, the gold standard for drug testing, are considered to be of high quality because the risk of bias is minimized. An RCT can provide evidence and can establish cause-and-effect relationships (hypothesis-testing).

Limitations:
RCT cannot readily be applied to nutrients as it is not possible to compare the effect of micronutrient-intake with a control group without any dietary exposure. So far, no good metrics or measures (i.e., for micronutrient efficacy) to establish a baseline for comparisons (i.e. effect with vs. without micronutrient) are available. on the influence of antioxidants on chemotherapy conclude that supplementation with antioxidants does not adversely affect chemotherapy.

Rather, it has a positive influence on the rate of side effects and tumor response. None of the studies examined in this context showed evidence of a significant adverse effect on the chemotherapy. However, many studies did show that supplementation with antioxidants increased either survival times, tumor response or both, and that they reduced the rate of side effects as compared with the control groups (9, 10).

The American Institute for Cancer Research (AICR) recommends that cancer patients undergoing chemo- or radiotherapy should not take multivitamin and mineral preparations containing daily doses of antioxidants greater than the corresponding tolerable upper intake levelsTolerable Upper Intake Level (UL)

The UL defines the maximum level of total chronic daily intake of a nutrient (from all sources) judged to be unlikely to pose a risk of adverse health effects to humans. ULs may be derived for various life stage groups in the population. (UL) for each individual micronutrient. According to AICR, supplementation with multivitamin and mineral preparations can generally be considered safe if the doses of vitamins and minerals are within the range of the recommended daily amounts (RDARecommended Daily Allowances or Recommended Dietary Allowances (RDA)

The daily dietary intake level of a nutrient considered sufficient to meet the requirements of nearly all (97–98%) healthy individuals in each life stage and gender group. ) (11). We recommend cancer patients with eating problems or weight loss in general to take a multivitamin/mineral combination based on RDAs in order to ensure the basic provision of essential micronutrients. This is principally to compensate for potential deficits, and not intended as a high-dose micronutrient therapy. Patients could benefit from taking some micronutrients, such as vitamin D, selenium and L-carnitine, in higher doses, depending on their tumor destruction therapy and laboratory status.” https://www.cancertutor.com/rath/

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