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In oncology, the Warburg effect is the observation that most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in the mitochondria as in most normal cells. The latter process is aerobic (uses oxygen). Malignant, rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin; this may occur even if oxygen is plentiful.
The Warburg effect may simply be a consequence of damage to the mitochondria in cancer, or an adaptation to low-oxygen environments within tumors, or a result of cancer genes shutting down the mitochondria. Because they are involved in the cell’s apoptosis program which would otherwise kill cancerous cells. It may also be an effect associated with cell proliferation. Since glycolysis provides most of the building blocks required for cell proliferation, cancer cells (and normal proliferating cells) have been proposed to need to activate glycolysis, despite the presence of oxygen, to proliferate.
Evidence attributes some of the high aerobic glycolytic rates to an overexpressed form of mitochondrially bound hexokinase responsible for driving the high glycolytic activity. In kidney cancer, this effect could be due to the presence of mutations in the Von Hippel–Lindau tumor suppressor gene upregulating glycolytic enzymes, including the M2 splice isoform of pyruvate kinase.]
In March 2008, Lewis C. Cantley and colleagues announced that the tumor M2-PK, a form of the pyruvate kinaseenzyme, gives rise to the Warburg effect. Tumor M2-PK is produced in all rapidly dividing cells, and is responsible for enabling cancer cells to consume glucose at an accelerated rate; on forcing the cells to switch to pyruvate kinase’s alternative form by inhibiting the production of tumor M2-PK, their growth was curbed. The researchers acknowledged the fact that the exact chemistry of glucose metabolism was likely to vary across different forms of cancer. However, PKM2 was identified in all of the cancer cells they had tested. This enzyme form is not usually found in healthy tissue, though it is apparently necessary when cells need to multiply quickly, e.g. in the healing of wounds or hematopoiesis.
I highly recommend a visit to the Millersburg – Berlin/ Charm area in OHIO. With the rolling hills and breath taking scene vista this would be a perfect location for a sleigh ride. This past weekend I drove over from my home in Western Ohio …. to witness a Facebook friends fathers miraculous recovery from chemotherapy to visit with the Amish Healer Jacob.
Since their settlement in the early 1800s …. the Amish have contributed to an unique economy. And in Jacobs 76 years he has witness a community change from 90% farming to a modern change of less than 10 percent today. With it he is witnessing greater illness and rising cancer rates from 40% of that of the rest of the State of OHIO.
Todays Amish Life is based upon construction crews, shops and stores and other diversity that keeps Amish Life close to home. Also sustaining Amish Life is becoming more of challenge in America when the Big Plan in Government is to allow family values to wither behind. With increase pressures and stress nobody knows what the future holds.
To some is dysfunction in family life: for the Amish its puzzling they, have not only, survive, but also thrive through the malaise of the rest of the United State Economy. Through strong family, they still eat together at one table and the fact that Amish populations double every 20 years with on average seven children.
However, as the market forces people to change what they believe in. And as the interact with the tempting culture of modern life (both good and bad aspect.) With fast food joints showing up in their culture I believe you will soon see a spike in the cancer rates of the Amish Life style and communities.
So this past weekend I came to Holmes County … to shake hands with a
Facebook friend Lynsi’s father John and wife Joyce and a cousin Kathleen (whom being a 8 year glioblastoma mutliforme survivor of the brain …it made for an incredible day. Also for John being treated at
The Family Health Center @ Cleveland Clinic in Wooster he has made a remarkable recovery through lifestyle change.
With the initiative of this trip to visit with “Jacob the Amish Healer” getting a different outlook on how cancer might be address. My first question being … what herbs would you suggest for cancer. To my surprised his reaction was cancer is about more than just herbs …. one must understand the work of Warburg, John Beard and William Kelley he stated 🙂
As we sit their in his cellular office we sit and talked about his view of Warburg and his theory of Oxygen respiration, carbon dioxide being expelled that create energy for cells. And when one doesn’t get the oxygen through vigorous activity how carbon dioxide can create lactic acid in the body. Which creates less trypsin enzymes and becomes the perfect breeding ground for cancer.
Hypercarbia or hypercapnia is the condition that occurs when carbon dioxide is retained in the lungs. As carbon dioxide accumulates in the lungs, it does not allow for the effective exchange of carbon dioxide and oxygen. As a result, carbon dioxide accumulates in the bloodstream. If the problem is not corrected, the blood eventually becomes acidic, a condition known as respiratory acidosis. The acidity causes oxygen molecules to drop out of the bloodstream too quickly. According to the University of Maryland Medical Center, this combination of high carbon dioxide levels and low oxygen levels creates a harsh body environment and places stress on the cells, tissues and organs. ~Stress can trip up trypsin – along with a faulty diet. ~
Jacob also told all one has to do is think back to 1902, when Dr. John Beard theorized that malignant cells are false placentas and that substances secreted by the pancreas would inhibit their growth of cancer before they develop. With increase carbon dioxide in the blood this critical enzyme becomes missing in most cancer patients.
What Dr. Beard explained back then was that the secret to how enzymes work is distinguishing between the good healthy cells and the bad cancerous “tumor cells.” What trypsin can do … is breakdown the right handed protein cancerous cells while living the left handed protein healthy living cells intact.
Therefore, the tumor creates a tumor made up of enzymes called malignins which is a mirror image of trypsin. Trypsin will only digest the protein of the tumor and what Beard believed back in the early 1900s… was that it had to be injected to prevent destruction by the hydrochloric acid in our stomach lining. However, recent evidence demonstrates that orally ingested enzymes are acid stable.
Thereby, stays intact into the small intestine and being readily absorbed through the intestinal mucosa into the blood stream as part of the enterpancreatic recycling process. Also in 1963, a dentist William Kelley … was diagnosed with pancreatic cancer (which is almost always deadly). Kelley rediscovered the connection between pancreatic enzymes and cancer remission.
What Kelley recommends is high amounts of pancreatic enzymes (45,000mg orally). This formula includes starch based enzymes, which Kelley also states is important. The formula Kelley stands behind cost roughly $2,000 monthly. Unfortunately. the larger the mass –which quickly dissolves from oral induced — enzyme therapy.
The harder it is for the liver/ kidney to rid the body of these toxins. As a result, many cancer patients taking enzymes die from toxemia …. as the tumor is digested. Various methods for detoxing the liver are known, with the coffee enema being preferred. Toxemia is the primary reason to have malignant tumors removed surgically.
Other Research to Consider:
The University of Michigan has recently proclaimed that current chemotherapy targets the wrong cells. This Ann Harbor research study discovered that not all cancerous cells in a tumor are equally malignant. Only a tiny minority of tumor cells are actually capable of inducing new cancers and that the rest are relatively harmless.
“These tumor-inducing cells have many of the properties of stem cells,” said Michael F. Clarke, MD., a professor of internal medicine, whom also directed the study. They make copies of themselves — a process called cell self — renewal – and produce all the other kinds of cells in the original tumor.”
The laetrile clinics in Mexico claim they have a “100%” cure rate for cancer. And they do a post disclaimer stating, “that 100% cure rate applies only if the patient has not under gone “chemotherapy” or “radiation” and only in those patients that take the pancreatic enzymes.
Another important discovery is that trypsin’s digestive enzyme action is activated by the high pH (alkaline) environment in the small intestine. This finding may help explain the effectiveness of the increasingly popular high-pH cesium treatment for cancer. There are theoretical reasons and experimental findings suggesting.
While it is unknown whether or not the cesium protocol works in complete absence of trypsin in the blood. It is logical to assume that less pancreatic enzymes would be required in conjunction with cesium treatment for cancer. Perhaps 4,500 mg of pancreatic enzymes with trypsin would suffice … along with 6,000 mg of cesium chloride daily, rather than the 45,000 mg that Kelley and Gonzalez recommends. With Experimental science will someday provide the answer.
Another intriguing possibility: if heavy metal mercury building up in the pancreas was the root cause of the enzyme secretion problem. Large amounts of vitamin C might cure a cancer (cause remission) by ridding the pancreas of mercury. Also if CoQ10 deficiency was the reason the pancreas was malfunctioning. Then supplementing CoQ10 may restart the production of trypsin, et cetera. Beards theory shows why some treatments work for some not others !!!!
There are sound reason to add 400mg of highly absorbable CoQ10 to any cancer protocol. This dosage has initiated complete tumor regression in breast cancer patients — during clinical studies. Since the pancreas has a high concentration of CoQ10, it may be that restoring CoQ10 levels improves pancreas function.
The Basic Recommendation for Controlling Cancer is:
1. Have surgery to remove as much of the tumor mass as possible.
3. Purchase pancreatic enzymes (The Dr. Max Wolf oncologic formula Wobenzyme.)
The formula must contain both trypsin and chymotrypsin. Start with 400 mg daily and
slowly increase until effective !!
4. Follow the Brewer Cesium Protocol (including laetrile — apricot seeds for 30 days.
One seed for 10 pounds of body weight.
5. Add a good mineral / multi-vitamin to cover all possible nutritional needs.
6. Supplement vitamin D and vitamin K (both have shown anti- cancer properties.
7. Avoid refined carbohydrates especially sugar that feeds cancer.
8. Avoid supplemental calcium (calcium can spread cancer)
Take supplemental magnesium/potassium if needed.
9. Eat protein every other day to rest the pancreas.
10. Eat Vegetables and fruit (berries). Avoid grains which include gluten.
**** Other orthomolecular substance include:
– ginger – lycopene – alpha lipoic acid
If these substances are effective they will restore pancreatic function…
or help inhibit the growth of the tumor and spread of cancer !!!!!!
